Introduction: Precision medicine is the concept of treating diseases based on environmental
factors, lifestyles, and molecular profiles of patients. This approach has been found to …

PURPOSE Cancer classification is foundational for patient care and oncology research.
Systems such as International Classification of Diseases for Oncology (ICD-O) …

Clinical trials represent a fulcrum for oncology drug discovery and development to bring safe
and effective medicines to patients in a timely manner. Clinical trials have shifted from …

Tumor molecular profiling of single gene-variant ('first-order') genomic alterations informs
potential therapeutic approaches. Interactions between such first-order events and global …

Clinicians in molecular tumor boards (MTB) are confronted with a growing amount of genetic
high-throughput sequencing data. Today, at German university hospitals, these data are …

PURPOSE Comprehensive genomic profiling to inform targeted therapy selection is a
central part of oncology care. However, the volume and complexity of alterations uncovered …

Background Molecular tumor boards (MTBs) cope with the complexity of an increased usage
of genome sequencing data in cancer treatment. As for most of these patients, guideline …

A fundamental challenge of modern biomedical research is understanding how diseases
that are similar on the phenotypic level are similar on the molecular level. Integration of …

Background Precision oncology relies on molecular diagnostics, and the value-proposition
of modern healthcare networks promises a higher standard of care across partner sites. We …

PURPOSE To inform precision oncology, methods are needed to use electronic health
records (EHRs) to identify patients with cancer who are experiencing clinical inflection …