Lytic polysaccharide monooxygenases (LPMOs) constitute an enigmatic class of enzymes,
the discovery of which has opened up a new arena of riveting research. LPMOs can …

About a 100 years ago, the Drosophila white mutant marked the birth of Drosophila genetics.
The white gene turned out to encode the first well studied ABC transporter in arthropods …

The human genome encodes approximately 20,000 proteins, many still uncharacterised. It
has become clear that scientific research tends to focus on well-studied proteins, leading to …

The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9
system for genome editing has greatly expanded the toolbox for mammalian genetics …

Thermobia domestica belongs to an ancient group of insects and has a remarkable ability to
digest crystalline cellulose without microbial assistance. By investigating the digestive …

An essential prerequisite for any systems-level understanding of cellular functions is to
correctly uncover and annotate all functional interactions among proteins in the cell. Toward …

Notch signalling links the fate of one cell to that of an immediate neighbour and
consequently controls differentiation, proliferation and apoptotic events in multiple metazoan …

Invertebrate model systems are powerful tools for studying human disease owing to their
genetic tractability and ease of screening. We conducted a mosaic genetic screen of lethal …

Gene silencing through RNA interference (RNAi) has revolutionized the study of gene
function, particularly in non-model insects. However, in Lepidoptera (moths and butterflies) …

RNAi is a potent technique for the knockdown of target genes. However, its potential off-
target effects limit the widespread applications in both reverse genetic analysis and genetic …