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[HTML][HTML] Nrf2 and oxidative stress: A general overview of mechanisms and implications in human disease
Organisms are continually exposed to exogenous and endogenous sources of reactive
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …
An update of Nrf2 activators and inhibitors in cancer prevention/promotion
Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …
factor that defends against endogenous or exogenous stressors. By inducing several …
Activators and inhibitors of NRF2: a review of their potential for clinical development
N Robledinos-Antón… - Oxidative medicine …, 2019 - Wiley Online Library
The transcription factor NRF2 (nuclear factor erythroid 2‐related factor 2) triggers the first
line of homeostatic responses against a plethora of environmental or endogenous …
line of homeostatic responses against a plethora of environmental or endogenous …
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer
D Shin, EH Kim, J Lee, JL Roh - Free Radical Biology and Medicine, 2018 - Elsevier
Abstract Glutathione peroxidase 4 (GPX4) is a regulator of ferroptosis (iron-dependent, non-
apoptotic cell death); its inhibition can render therapy-resistant cancer cells susceptible to …
apoptotic cell death); its inhibition can render therapy-resistant cancer cells susceptible to …
The role of reactive oxygen species in arsenic toxicity
Y Hu, J Li, B Lou, R Wu, G Wang, C Lu, H Wang, J Pi… - Biomolecules, 2020 - mdpi.com
Arsenic poisoning is a global health problem. Chronic exposure to arsenic has been
associated with the development of a wide range of diseases and health problems in …
associated with the development of a wide range of diseases and health problems in …
The KEAP1–NRF2 system in cancer
Cancer cells first adapt to the microenvironment and then propagate. Mutations in tumor
suppressor genes or oncogenes are frequently found in cancer cells. Comprehensive …
suppressor genes or oncogenes are frequently found in cancer cells. Comprehensive …
[HTML][HTML] Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers
L Lin, Q Wu, F Lu, J Lei, Y Zhou, Y Liu, N Zhu… - Frontiers in …, 2023 - frontiersin.org
Cancer is a borderless global health challenge that continues to threaten human health.
Studies have found that oxidative stress (OS) is often associated with the etiology of many …
Studies have found that oxidative stress (OS) is often associated with the etiology of many …
[HTML][HTML] The multifaceted roles of NRF2 in Cancer: friend or foe?
C Glorieux, C Enríquez, C González… - Antioxidants, 2024 - mdpi.com
Physiological concentrations of reactive oxygen species (ROS) play vital roles in various
normal cellular processes, whereas excessive ROS generation is central to disease …
normal cellular processes, whereas excessive ROS generation is central to disease …
The hallmarks of flavonoids in cancer
Flavonoids represent an important group of bioactive compounds derived from plant-based
foods and beverages with known biological activity in cells. From the modulation of …
foods and beverages with known biological activity in cells. From the modulation of …
Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]‐gingerol in cancer: A comprehensive review
RMT de Lima, AC Dos Reis… - Phytotherapy …, 2018 - Wiley Online Library
Natural dietary agents have attracted considerable attention due to their role in promoting
health and reducing the risk of diseases including cancer. Ginger, one of the most ancient …
health and reducing the risk of diseases including cancer. Ginger, one of the most ancient …