Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Ion mobility spectrometry is an analytical technique known for more than 100 years, which
entails separating ions in the gas phase based on their size, shape, and charge. While ion …

In recent years, small protein oligomers have been implicated in the aetiology of a number of
important amyloid diseases, such as type 2 diabetes, Parkinson's disease and Alzheimer's …

The technique of ion mobility mass spectrometry (IM-MS) has become of increasing interest
for rapid analysis of the conformations adopted by biological macromolecules. It is currently …

The electrodynamic ion funnel has enabled the manipulation and focusing of ions in a
pressure regime (0.1–30 Torr) that has challenged traditional approaches, and provided the …

In this Review, we focus on an important aspect of ion mobility (IM) research, namely, the
reporting of quantitative ion mobility measurements in the form of the gas-phase collision …

The conformations of desolvated ubiquitin ions, lifted into the gas phase by electrospray
ionization (ESI), were characterized by ion mobility spectrometry (IMS) and compared to the …

Self-aggregation of the microtubule-binding protein Tau reduces its functionality and is
tightly associated with Tau-related diseases, termed tauopathies. Tau aggregation is also …

Oligomerization of human islet amyloid polypeptide (IAPP) has been increasingly
considered a pathogenic process in type II diabetes. Here structural features of the IAPP …

Phosphorylation is one the most studied and important post translational modifications.
Nano electrospray mass spectrometry coupled with traveling wave (T-Wave)-based ion …