Influenza is a long-standing health problem. For treatment of seasonal flu and possible
pandemic infections, there is a need to develop new anti-influenza drugs that have good …

In consequence of their biological effects, conformationally constrained carbocyclic β-amino
acids have generated great interest among synthetic and medicinal chemists in the past 2 …

Influenza, a severe viral infection of the respiratory system, is responsible for a significant
morbidity and mortality due to both annual epidemics and unpredictable pandemics. In the …

Glycosidases are ubiquitous enzymes involved in a diversity of key biological processes
such as energy uptake or cell wall degradation. The design of specific glycosidase inhibitors …

A bunch of keys, one lock: The multivalent effect in glycosidase inhibition is a new, rapidly
emerging area with exciting potential and scope. This review presents a description of the …

During the last decades, tremendous chemical efforts have been dedicated to design
monovalent inhibitors of carbohydrate‐processing enzymes, with comparatively few rewards …

The neuraminidase (NA) of influenza A and B viruses plays a distinct role in viral replication
and has a highly conserved catalytic site. Numerous sialic (neuraminic) acid analogs that …

The influenza pandemic is a major threat to human health, and highly aggressive strains
such as H1N1, H5N1 and H7N9 have emphasized the need for therapeutic strategies to …

Multivalent nanoconstructs, extensively used for enhancing the recognition of biomolecular
targets, have been recently exploited for enzyme inhibition showing interesting properties …

Seasonal and pandemic influenza have caused high morbidity and mortality worldwide.
Recent emergence of influenza A H5N1 and H1N1 strains has heightened concern …