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Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and
an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major …

Angiogenesis is thought to depend on a precise balance of positive and negative regulation.
Angiopoietin-1 (Ang1) is an angiogenic factor that signals through the endothelial cell …

Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular
endothelial cells. Five VEGF isoforms are generated as a result of alternative splicing from a …

Novel anti-neoplastic agents such as gene targeting vectors and encapsulated carriers are
quite large (approximately 100–300 nm in diameter). An understanding of the functional size …

New blood vessel formation (angiogenesis) is a fundamental event in the process of tumor
growth and metastatic dissemination. Hence, the molecular basis of tumor angiogenesis has …

VPF/VEGF is a multifunctional cytokine that contributes to angiogenesis by both direct and
indirect mechanisms. On the one hand, VPF/VEGF stimulates the ECs lining nearby …

Vascular endothelial growth factor (VEGF), a major regulator of angiogenesis, binds to two
receptor tyrosine kinases, KDR/Flk-1 and Flt-1. We now describe the purification and the …

Evidence accumulating over the last decade has established the fundamental role of
vascular endothelial growth factor (VEGF) as a key regulator of normal and abnormal …

Vascular endothelial growth factor (VEGF) is a fundamental regulator of normal and
abnormal angiogenesis. Recent evidence indicates that VEGF is essential for embryonic …