Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In …

Artificial intelligence-based protein structure prediction methods such as AlphaFold have
revolutionized structural biology. The accuracies of these predictions vary, however, and …

Over the last decade, molecular systematics has undergone a change of paradigm as high-
throughput sequencing now makes it possible to reconstruct evolutionary relationships …

Premise of the Study Large phylogenies can help shed light on macroevolutionary patterns
that inform our understanding of fundamental processes that shape the tree of life. These …

Phylogenomic studies have resolved countless branches of the tree of life, but remain
strongly contradictory on certain, contentious relationships. Here, we use a maximum …

Genomics is narrowing uncertainty in the phylogenetic structure for many amniote groups.
For one of the most diverse and species-rich groups, the squamate reptiles (lizards, snakes …

Molecular phylogenies have yielded strong support for many parts of the amphibian Tree of
Life, but poor support for the resolution of deeper nodes, including relationships among …

Phylogenomic analyses have helped resolve many recalcitrant relationships in the
angiosperm tree of life, yet phylogenetic resolution of the backbone of the Leguminosae …

Phylogenomics is extremely powerful but introduces new challenges as no agreement exists
on 'standards' for data selection, curation and tree inference. We use jawed vertebrates …

Phylogenomic subsampling is a procedure by which small sets of loci are selected from
large genome-scale data sets and used for phylogenetic inference. This step is often …