Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …

Recent studies have begun to reveal critical roles for the brain's professional phagocytes,
microglia, and their receptors in the control of neurotoxic amyloid beta (Aβ) and myelin …

Genome-wide association studies have discovered numerous genomic loci associated with
Alzheimer's disease (AD); yet the causal genes and variants are incompletely identified. We …

Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

There is growing evidence that excessive microglial phagocytosis of neurons and synapses
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …

A major challenge in the field of neurodegenerative diseases and brain aging is to identify
the body's intrinsic mechanism that could sense the central nervous system (CNS) damage …

Proliferation and activation of microglia in the brain, concentrated around amyloid plaques,
is a prominent feature of Alzheimer's disease (AD). Human genetics data point to a key role …

Sialic acid–binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of
white blood cells of the immune system and play critical roles in immune cell signaling …