Troponin I (TnI) is the inhibitory subunit of the troponin complex in the sarcomeric thin
filament of striated muscle and plays a central role in the calcium regulation of contraction …

Restrictive cardiomyopathy is a rare cardiac disease causing severe diastolic dysfunction,
ventricular stiffness and dilated atria. In consequence, it induces heart failure often with …

Background Mouse models of heart disease are extensively employed. The
echocardiographic characterization of contractile function is usually focused on systolic …

Cardiomyopathies represent a heterogeneous group of diseases that negatively affect heart
function. Primary cardiomyopathies specifically target the myocardium, and may arise from …

Restrictive cardiomyopathy (RCM) is defined as increased myocardial stiffness and impaired
diastolic relaxation leading to elevated ventricular filling pressures. Human variants in …

Mammalian cardiac troponin I (cTnI) contains a highly conserved amino-terminal extension
harboring protein kinase A targets [serine-23 and-24 (Ser23/24)] that are phosphorylated …

The troponin complex—consisting of three subunits: troponin C (TnC), cardiac troponin I
(cTnI) and cardiac troponin T (cTnT)—plays a key role in the regulation of myocardial …

Background—Hypertrophic cardiomyopathy (HCM) is a common genetic disorder caused
mainly by mutations in sarcomeric proteins and is characterized by maladaptive myocardial …

The impaired ability of the heart to relax and stretch to accommodate venous return is
generally understood to represent a state of “diastolic dysfunction” and often described …

Troponin plays a central role in regulating the contraction and relaxation of vertebrate
striated muscles. This review focuses on the isoform gene regulation, alternative RNA …