The development of therapeutic approaches for the induction of robust, long-lasting and
antigen-specific immune tolerance remains an important unmet clinical need for the …

Regulatory T cells (Treg cells) are key players in ensuring a peaceful coexistence with
microorganisms and food antigens at intestinal borders. Startling new information has …

The intestinal epithelial cells (IECs) constitute the primary barrier between host cells and
numerous foreign antigens; it is unclear how IECs induce the protective immunity against …

Aberrant immune responses to resident microbes promote inflammatory bowel disease and
other chronic inflammatory conditions. However, how microbiota-specific immunity is …

In the past few decades, a number of transformative discoveries have been made regarding
memory CD8+ T cell biology; meanwhile, the CD4+ T cell field has lagged behind this …

Celiac disease (CeD) is a widespread, gluten-induced, autoimmune disorder that lacks any
medicinal therapy. Towards the goal of develo** non-dietary treatments for CeD, research …

Periodontitis and inflammatory bowel diseases (IBD) are inflammatory diseases of the
gastrointestinal tract that share common features of microbial-induced ecological …

The incomplete removal of T cells that are reactive against self-proteins during their
differentiation in the thymus requires mechanisms of tolerance that prevent their effector …

The intestinal immune system must tolerate food antigens to avoid allergy, a process
requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we …

Autoimmune liver diseases include primary biliary cholangitis, primary sclerosing
cholangitis, and autoimmune hepatitis, a family of chronic immune-mediated disorders that …