Organic halides are very important and versatile compounds with many applications as
starting materials, solvents, reagents, and intermediates in synthetic organic chemistry. 1 …

The synthesis of ketones from carboxylic acids or their derivatives is an important synthetic
operation whereby CC bond construction and functional group interconversion is achieved …

In sharp contrast to the use of conventional magnesium‐based Grignard reagents (R− MgX),
the application of calcium‐based heavy Grignard reagents (R− CaX) in organic synthesis …

The microreactor technology is an efficient tool for kilogram-scale syntheses in continuous
mode and is particularly effective for hazardous reactions that do not allow scale-up in …

The extent to which coordinated ligands influence the chemistry of metal complexes varies
greatly across the periodic table. The transition metals support a rich variety of ligand …

The sensitivity provided by fluorescence microscopy enabled the observation of surface
intermediates in the synthesis of soluble organozinc reagents by direct insertion of alkyl …

Since the first report and due to its handiness and wide scope, the Suzuki-Miyaura (SM)
cross coupling reaction has become a routine methodology in many laboratories worldwide …

Today, the synthetic chemist has a large repertoire of metal activation methods at his
disposal. After a first breakthrough was made at the beginning of the seventies with the …

Compounds of the type aryl M X, with M= Ca, Sr, Ba and X as any kind of ligand (such as
halide, phosphanide, amide, aryl), are presented. The low reactivity of the heavy alkaline …

The palladium acetate-catalyzed coupling reaction of aryl boronic acid with carboxylic
anhydride or acyl chloride was carried out smoothly in water in the presence of poly …