Structural and chemical biology of terpenoid cyclases
DW Christianson - Chemical reviews, 2017 - ACS Publications
The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …
Metabolic engineering of Escherichia coli for natural product biosynthesis
Natural products are widely employed in our daily lives as food additives, pharmaceuticals,
nutraceuticals, and cosmetic ingredients, among others. However, their supply has often …
nutraceuticals, and cosmetic ingredients, among others. However, their supply has often …
Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis
The diterpenoid paclitaxel (Taxol) is a chemotherapy medication widely used as a first-line
treatment against several types of solid cancers. The supply of paclitaxel from natural …
treatment against several types of solid cancers. The supply of paclitaxel from natural …
Reconstitution of early paclitaxel biosynthetic network
Paclitaxel is an anticancer therapeutic produced by the yew tree. Over the last two decades,
a significant bottleneck in the reconstitution of early paclitaxel biosynthesis has been the …
a significant bottleneck in the reconstitution of early paclitaxel biosynthesis has been the …
Protein engineering for improving and diversifying natural product biosynthesis
Proteins found in nature have traditionally been the most frequently used biocatalysts to
produce numerous natural products ranging from commodity chemicals to pharmaceuticals …
produce numerous natural products ranging from commodity chemicals to pharmaceuticals …
Current perspectives on taxanes: Focus on their bioactivity, delivery and combination therapy
J Škubník, V Pavlíčková, T Ruml, S Rimpelová - Plants, 2021 - mdpi.com
Taxanes, mainly paclitaxel and docetaxel, the microtubule stabilizers, have been well known
for being the first-line therapy for breast cancer for more than the last thirty years. Moreover …
for being the first-line therapy for breast cancer for more than the last thirty years. Moreover …
Identifying and engineering the ideal microbial terpenoid production host
S Moser, H Pichler - Applied Microbiology and Biotechnology, 2019 - Springer
More than 70,000 different terpenoid structures are known so far; many of them offer highly
interesting applications as pharmaceuticals, flavors and fragrances, or biofuels. Extraction of …
interesting applications as pharmaceuticals, flavors and fragrances, or biofuels. Extraction of …
Unraveling the catalytic mechanism of taxadiene-5α-hydroxylase from crystallography and computational analyses
X Song, Q Wang, X Zhu, W Fang, X Liu, C Shi… - ACS …, 2024 - ACS Publications
Paclitaxel is a famous chemotherapeutic agent, but its microbial production poses a long-
standing challenge due to its poor product selectivity. Taxadiene-5α-hydroxylase …
standing challenge due to its poor product selectivity. Taxadiene-5α-hydroxylase …
Recent advances of metabolic engineering strategies in natural isoprenoid production using cell factories
Covering: up to 2019 As abundant natural products, isoprenoids have many useful industrial
applications in the manufacturing of drugs, fragrances, food additives, colorants, rubber and …
applications in the manufacturing of drugs, fragrances, food additives, colorants, rubber and …
Hydroxylases involved in terpenoid biosynthesis: a review
Z Zhang, QY Wu, Y Ge, ZY Huang, R Hong, A Li… - Bioresources and …, 2023 - Springer
Terpenoids are pervasive in nature and display an immense structural diversity. As the
largest category of plant secondary metabolites, terpenoids have important socioeconomic …
largest category of plant secondary metabolites, terpenoids have important socioeconomic …