Advances in technology have allowed for the sensitive, specific, and simultaneous
quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites …

The collection of microbes that live in and on the human body–the human microbiome–can
impact on cancer initiation, progression, and response to therapy, including cancer …

The human gut microbiome harbors hundreds of bacterial species with diverse biochemical
capabilities. Dozens of drugs have been shown to be metabolized by single isolates from …

Recent studies suggest that human-associated bacteria interact with host-produced steroids,
but the mechanisms and physiological impact of such interactions remain unclear. Here, we …

Fibromyalgia (FM) is a prevalent syndrome, characterised by chronic widespread pain,
fatigue, and impaired sleep, that is challenging to diagnose and difficult to treat. The …

Globally,~ 8%− 12% of couples confront infertility issues, male-related issues being
accountable for 50%. This review focuses on the influence of gut microbiota and their …

Natural products are a rich resource for the discovery of innovative drugs. Microbial
cocultivation enables discovery of novel natural products through tandem enzymatic …

Bile acids (BA) are among the most abundant metabolites produced by the gut microbiome.
Primary BAs produced in the liver are converted by gut bacterial 7-α-dehydroxylation into …

The gut microbiota, a large ecosystem interacting with the host, has been shown to affect the
health and fitness of the host-microbial superorganism. Increasing evidence suggests that …

Bile acids (BAs) and glucocorticoids are steroid hormones derived from cholesterol that are
important signaling molecules in humans and other vertebrates. Hydroxysteroid …