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Calibration of ionic and cellular cardiac electrophysiology models
Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …
mathematical models of biological systems. This maturity is bringing new challenges as …
Validation and trustworthiness of multiscale models of cardiac electrophysiology
Computational models of cardiac electrophysiology have a long history in basic science
applications and device design and evaluation, but have significant potential for clinical …
applications and device design and evaluation, but have significant potential for clinical …
Cell-specific cardiac electrophysiology models
The traditional cardiac model-building paradigm involves constructing a composite model
using data collected from many cells. Equations are derived for each relevant cellular …
using data collected from many cells. Equations are derived for each relevant cellular …
Four ways to fit an ion channel model
Mathematical models of ionic currents are used to study the electrophysiology of the heart,
brain, gut, and several other organs. Increasingly, these models are being used predictively …
brain, gut, and several other organs. Increasingly, these models are being used predictively …
Uncertainty quantification of fast sodium current steady-state inactivation for multi-scale models of cardiac electrophysiology
Perhaps the most mature area of multi-scale systems biology is the modelling of the heart.
Current models are grounded in over fifty years of research in the development of …
Current models are grounded in over fifty years of research in the development of …
Bayesian inference for fitting cardiac models to experiments: estimating parameter distributions using Hamiltonian Monte Carlo and approximate Bayesian …
Customization of cardiac action potential models has become increasingly important with
the recognition of patient-specific models and virtual patient cohorts as valuable predictive …
the recognition of patient-specific models and virtual patient cohorts as valuable predictive …
Hodgkin–Huxley revisited: reparametrization and identifiability analysis of the classic action potential model with approximate Bayesian methods
As cardiac cell models become increasingly complex, a correspondingly complex
'genealogy'of inherited parameter values has also emerged. The result has been the loss of …
'genealogy'of inherited parameter values has also emerged. The result has been the loss of …
Inference-based assessment of parameter identifiability in nonlinear biological models
As systems approaches to the development of biological models become more mature,
attention is increasingly focusing on the problem of inferring parameter values within those …
attention is increasingly focusing on the problem of inferring parameter values within those …
[HTML][HTML] Reproducible model development in the cardiac electrophysiology Web Lab
The modelling of the electrophysiology of cardiac cells is one of the most mature areas of
systems biology. This extended concentration of research effort brings with it new …
systems biology. This extended concentration of research effort brings with it new …
Parameter identifiability and identifiable combinations in generalized Hodgkin–Huxley models
Abstract The use of Hodgkin–Huxley (HH) equations abounds in the literature, but the
identifiability of the HH model parameters has not been broadly considered. Identifiability …
identifiability of the HH model parameters has not been broadly considered. Identifiability …