The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory
factor (TRF) that controls many distinct gene networks, each uniquely determined by …

Skeletal muscle, the largest organ in the human body, accounting for approximately 40% of
body weight, plays important roles in exercise and energy expenditure. In the elderly, there …

Emerging evidence indicates a fundamental role for the epigenome in immunity. Here, we
mapped the epigenomic and transcriptional landscape of immunity to influenza vaccination …

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

In mammalian cells, two cellular organelles, mitochondria and peroxisomes, share the ability
to degrade fatty acid chains. Although each organelle harbors its own fatty acid β-oxidation …

Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers. We
performed exome sequencing on 113 tumor-normal pairs, yielding a mean of 82 non-silent …

Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …

Glucocorticoid hormones regulate essential body functions in mammals, control cell
metabolism, growth, differentiation, and apoptosis. Importantly, they are potent suppressors …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

The transcriptional coactivators CREB-binding protein (CBP) and p300 undergo a
particularly rich set of interactions with disordered and partly ordered partners, as a part of …