Imaging cholinergic receptors in the brain by positron emission tomography
JJ Zhang, H Fu, R Lin, J Zhou, A Haider… - Journal of Medicinal …, 2023 - ACS Publications
Cholinergic receptors represent a promising class of diagnostic and therapeutic targets due
to their significant involvement in cognitive decline associated with neurological disorders …
to their significant involvement in cognitive decline associated with neurological disorders …
Inflammation in stroke: the role of cholinergic, purinergic and glutamatergic signaling
The inflammatory response is a major factor in stroke pathophysiology and contributes to
secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent …
secondary neuronal damage in both acute and chronic stages of the ischemic injury. Recent …
PET imaging of α7 nicotinic acetylcholine receptors: a comparative study of [18F]ASEM and [18F]DBT-10 in nonhuman primates, and further evaluation of [18F] …
Purpose The α 7 nicotinic acetylcholine receptor (nAChR) is implicated in many
neuropsychiatric disorders, making it an important target for positron emission tomography …
neuropsychiatric disorders, making it an important target for positron emission tomography …
Current radiotracers to image neurodegenerative diseases
The term of neurodegenerative diseases covers a heterogeneous group of disorders that
are distinguished by progressive degeneration of the structure and function of the nervous …
are distinguished by progressive degeneration of the structure and function of the nervous …
Positron emission tomography in animal models of tauopathies
L Cao, Y Kong, BIN Ji, Y Ren, Y Guan… - Frontiers in Aging …, 2022 - frontiersin.org
The microtubule-associated protein tau (MAPT) plays an important role in Alzheimer's
disease and primary tauopathy diseases. The abnormal accumulation of tau contributes to …
disease and primary tauopathy diseases. The abnormal accumulation of tau contributes to …
PET imaging for early detection of Alzheimer's disease: from pathologic to physiologic biomarkers
W Bao, H Jia, S Finnema, Z Cai, RE Carson… - PET clinics, 2017 - pet.theclinics.com
Alzheimer's disease (AD) affects more than 35 million people worldwide, and the number is
estimated to quadruple in 40 years if there remains no cure. 1–4 AD is characterized by the …
estimated to quadruple in 40 years if there remains no cure. 1–4 AD is characterized by the …
Quantitative PET imaging in drug development: estimation of target occupancy
Positron emission tomography, an imaging tool using radiolabeled tracers in humans and
preclinical species, has been widely used in recent years in drug development, particularly …
preclinical species, has been widely used in recent years in drug development, particularly …
Potential of α7 nicotinic acetylcholine receptor PET imaging in atherosclerosis
E Boswijk, M Bauwens, FM Mottaghy, JE Wildberger… - Methods, 2017 - Elsevier
Atherosclerotic events are usually acute and often strike otherwise asymptomatic patients.
Although multiple clinical risk factors have been associated with atherosclerosis, as of yet no …
Although multiple clinical risk factors have been associated with atherosclerosis, as of yet no …
Radioligand binding analysis of α2 adrenoceptors with [11C]yohimbine in brain in vivo: Extended Inhibition Plot correction for plasma protein binding
We describe a novel method of kinetic analysis of radioligand binding to neuroreceptors in
brain in vivo, here applied to noradrenaline receptors in rat brain. The method uses positron …
brain in vivo, here applied to noradrenaline receptors in rat brain. The method uses positron …
In Vitro and In Vivo Characterization of Dibenzothiophene Derivatives [125I]Iodo-ASEM and [18F]ASEM as Radiotracers of Homo- and Heteromeric α7 Nicotinic …
The α7 nicotinic acetylcholine receptor (α7 nAChR) is involved in several cognitive and
physiologic processes; its expression levels and patterns change in neurologic and …
physiologic processes; its expression levels and patterns change in neurologic and …