Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

Several bone conditions, eg, bone cancer, osteoporosis, and rheumatoid arthritis (RA), are
associated with a risk of develo** persistent pain. Increased osteoclast activity is often the …

Cystic Fibrosis (CF) is an autosomal recessive disease caused by mutations in the CF
transmembrane regulator (CFTR) gene, which encodes a chloride channel located at the …

The realism and accuracy of lipid bilayer simulations through molecular dynamics (MD) are
heavily dependent on the lipid composition. While the field is pushing toward implementing …

Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary arterial hypertension
(PAH) occurring in a heritable form (hPVOD) due to biallelic inactivating mutations of …

The balance within phospholipids (PLs) between saturated fatty acids and monounsaturated
or polyunsaturated fatty acids is known to regulate the biophysical properties of cellular …

While approximately 2000 mutations have been discovered in the gene coding for the cystic
fibrosis transmembrane conductance regulator (CFTR), only a small amount (about 10%) is …

If polyunsaturated fatty acids (PUFAs) are generally accepted to be good for health, the
mechanisms of their bona fide benefits still remain elusive. Membrane phospholipids (PLs) …

Abstract Background The Mutation I1234V is a CF causing mutation; however the
mechanisms leading to loss of function are not fully understood. In this study, we aimed to …