Aneuploidy as a promoter and suppressor of malignant growth
Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …
but the connection between chromosomal errors and malignant growth has remained …
Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies
Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy
typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to …
typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to …
Chromosomal instability as enabling feature and central hallmark of breast cancer
G Castellanos, DS Valbuena, E Pérez… - … Cancer: Targets and …, 2023 - Taylor & Francis
Chromosomal instability (CIN) has become a topic of great interest in recent years, not only
for its implications in cancer diagnosis and prognosis but also for its role as an enabling …
for its implications in cancer diagnosis and prognosis but also for its role as an enabling …
Extensive protein dosage compensation in aneuploid human cancers
Aneuploidy is a hallmark of human cancers, but the effects of aneuploidy on protein
expression remain poorly understood. To uncover how chromosome copy number changes …
expression remain poorly understood. To uncover how chromosome copy number changes …
Whole-genome duplication shapes the aneuploidy landscape of human cancers
Aneuploidy is a hallmark of cancer with tissue-specific prevalence patterns that suggest it
plays a driving role in cancer initiation and progression. However, the contribution of …
plays a driving role in cancer initiation and progression. However, the contribution of …
Quantifying chromosomal instability from intratumoral karyotype diversity using agent-based modeling and Bayesian inference
Chromosomal instability (CIN)—persistent chromosome gain or loss through abnormal
mitotic segregation—is a hallmark of cancer that drives aneuploidy. Intrinsic chromosome …
mitotic segregation—is a hallmark of cancer that drives aneuploidy. Intrinsic chromosome …
Chromosome missegregation as a modulator of radiation sensitivity
PF Cosper, SE Copeland, JB Tucker… - Seminars in radiation …, 2022 - Elsevier
Chromosome missegregation over the course of multiple cell divisions, termed
chromosomal instability (CIN), is a hallmark of cancer. Multiple causes of CIN have been …
chromosomal instability (CIN), is a hallmark of cancer. Multiple causes of CIN have been …
Karyotype aberrations in action: the evolution of cancer genomes and the tumor microenvironment
Cancer is a disease of cellular evolution. For this cellular evolution to take place, a
population of cells must contain functional heterogeneity and an assessment of this …
population of cells must contain functional heterogeneity and an assessment of this …
The Promise of Combination Therapies with FOXM1 Inhibitors for Cancer Treatment
Simple Summary FOXM1 is an oncogenic transcription factor that has been implicated in
cancer progression, metastases, and chemotherapy resistance. Multiple small-molecule …
cancer progression, metastases, and chemotherapy resistance. Multiple small-molecule …
Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer
JS Lim, E Kim, JS Song, S Ahn - Oncology Reports, 2024 - spandidos-publications.com
Monopolar spindle 1 kinase (Mps1, also known as TTK protein kinase) inhibitors exert
marked anticancer effects against triple-negative breast cancer (TNBC) by causing genomic …
marked anticancer effects against triple-negative breast cancer (TNBC) by causing genomic …