Neuroimaging biomarkers for Alzheimer's disease

F Márquez, MA Yassa - Molecular neurodegeneration, 2019 - Springer
Currently, over five million Americans suffer with Alzheimer's disease (AD). In the absence of
a cure, this number could increase to 13.8 million by 2050. A critical goal of biomedical …

[HTML][HTML] Key clinical benefits of neuroimaging at 7 T

S Trattnig, E Springer, W Bogner, G Hangel, B Strasser… - Neuroimage, 2018 - Elsevier
The growing interest in ultra-high field MRI, with more than 35.000 MR examinations already
performed at 7 T, is related to improved clinical results with regard to morphological as well …

[HTML][HTML] A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI

JE Iglesias, JC Augustinack, K Nguyen, CM Player… - Neuroimage, 2015 - Elsevier
Automated analysis of MRI data of the subregions of the hippocampus requires
computational atlases built at a higher resolution than those that are typically used in current …

Characterizing the human hippocampus in aging and Alzheimer's disease using a computational atlas derived from ex vivo MRI and histology

DH Adler, LEM Wisse, R Ittyerah, JB Pluta… - Proceedings of the …, 2018 - pnas.org
Although the hippocampus is one of the most studied structures in the human brain, limited
quantitative data exist on its 3D organization, anatomical variability, and effects of disease …

Direct brain recordings reveal hippocampal rhythm underpinnings of language processing

V Piai, KL Anderson, JJ Lin, C Dewar, J Parvizi… - Proceedings of the …, 2016 - pnas.org
Language is classically thought to be supported by perisylvian cortical regions. Here we
provide intracranial evidence linking the hippocampal complex to linguistic processing. We …

A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals?

LEM Wisse, AM Daugherty, RK Olsen, D Berron… - …, 2017 - Wiley Online Library
The advent of high‐resolution magnetic resonance imaging (MRI) has enabled in vivo
research in a variety of populations and diseases on the structure and function of …

Automated hippocampal unfolding for morphometry and subfield segmentation with HippUnfold

J DeKraker, RAM Haast, MD Yousif, B Karat, JC Lau… - elife, 2022 - elifesciences.org
Like neocortical structures, the archicortical hippocampus differs in its folding patterns
across individuals. Here, we present an automated and robust BIDS-App, HippUnfold, for …

In vivo delineation of subdivisions of the human amygdaloid complex in a high‐resolution group template

JM Tyszka, WM Pauli - Human brain map**, 2016 - Wiley Online Library
The nuclei of the human amygdala remain difficult to distinguish in individual subject
structural magnetic resonance images. However, interpretation of the amygdala's role in …

[HTML][HTML] Test-retest reliability of FreeSurfer automated hippocampal subfield segmentation within and across scanners

EM Brown, ME Pierce, DC Clark, BR Fischl, JE Iglesias… - Neuroimage, 2020 - Elsevier
The human hippocampus is vulnerable to a range of degenerative conditions and as such,
accurate in vivo measurement of the hippocampus and hippocampal substructures via …

Hippocampal maturity promotes memory distinctiveness in childhood and adolescence

A Keresztes, AR Bender, NC Bodammer… - Proceedings of the …, 2017 - pnas.org
Adaptive learning systems need to meet two complementary and partially conflicting goals:
detecting regularities in the world versus remembering specific events. The hippocampus …