Lessons learnt from COVID-19: computational strategies for facing present and future pandemics

M Pavan, S Moro - International Journal of Molecular Sciences, 2023 - mdpi.com
Since its outbreak in December 2019, the COVID-19 pandemic has caused the death of
more than 6.5 million people around the world. The high transmissibility of its causative …

Metallodrug Profiling against SARS‐CoV‐2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain‐like Protease PLpro

M Gil‐Moles, S Türck, U Basu… - … A European Journal, 2021 - Wiley Online Library
The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
has called for an urgent need for dedicated antiviral therapeutics. Metal complexes are …

3-chymotrypsin-like protease in SARS-CoV-2

K Al Adem, JC Ferreira, AJ Villanueva, S Fadl… - Bioscience …, 2024 - portlandpress.com
Coronaviruses constitute a significant threat to the human population. Severe acute
respiratory syndrome coronavirus-2, SARS-CoV-2, is a highly pathogenic human …

Computational design of candidate multi-epitope vaccine against SARS-CoV-2 targeting structural (S and N) and non-structural (NSP3 and NSP12) proteins

Z Ali, JV Cardoza, S Basak, U Narsaria… - Journal of …, 2023 - Taylor & Francis
The COVID-19 pandemic caused by SARS-CoV-2 virus has created a global damage and
has exposed the vulnerable side of scientific research towards novel diseases. The intensity …

Computational biology assisted exploration of phytochemicals derived natural inhibitors to block BZLF1 gene activation of Epstein–Bar virus in host

M Naveed, M Hussain, T Aziz, N Hanif, N Kanwal… - Scientific Reports, 2024 - nature.com
Abstract The Epstein–Barr virus (EBV) is widespread and has been related to a variety of
malignancies as well as infectious mononucleosis. Despite the lack of a vaccination …

COVID-19 management landscape: a need for an affordable platform to manufacture safe and efficacious biotherapeutics and prophylactics for the develo** …

V Pidiyar, G Kumraj, K Ahmed, S Ahmed, S Shah… - Vaccine, 2022 - Elsevier
To gain world-wide control over COVID-19 pandemic, it is necessary to have affordable and
accessible vaccine and monoclonal antibody technologies across the globe. In comparison …

Repurposed therapeutic strategies towards COVID-19 potential targets based on genomics and protein structure remodeling

AK Singh, A Singh, AK Dubey - 2021 - books.google.com
Target recognition is important for the identification of drugs with a high target specificity
and/or for the development of existing drugs that could be replicated for the treatment of …

Enzima Conversora de Angiotensina 2 (ECA2) e sua susceptibilidade ao Sars-Cov-2

E de Souza Silva, J Ramos… - Brazilian Journal …, 2023 - ojs.brazilianjournals.com.br
A Síndrome Respiratória Aguda Grave do Coronavírus 2 (SARS-CoV-2), o agente causador
da Covid-19, é um vírus de RNA de fita simples de sentido positivo, cujo processo …

High throughput bioluminescent assay to characterize and monitor the activity of SARS-CoV-2 methyltransferases

K Hsiao, H Zegzouti, S Goueli - Plos one, 2022 - journals.plos.org
The fast rate of viral mutations of SARS CoV-2 result in decrease in the efficacy of the
vaccines that have been developed before the emergence of these mutations. Thus, it is …

Recent Advances in the Development of novel inhibitors targeting RNA Helicase Enzyme of SARS-CoV-2

R Satpathy, S Acharya - Journal of Biochemical Technology, 2023 - jbiochemtech.com
The rapid spread and infection rate of novel severe acute respiratory syndrome coronavirus
(SARS-CoV-2) has created a worldwide pandemic since its origin in 2019. Another concern …