Treatment of traumatic brain injury with anti-inflammatory drugs

PJ Bergold - Experimental neurology, 2016 - Elsevier
Traumatic brain injury rapidly induces inflammation. This inflammation is produced both by
endogenous brain cells and circulating inflammatory cells that enter from the brain. Together …

Therapies negating neuroinflammation after brain trauma

S Hellewell, BD Semple, MC Morganti-Kossmann - Brain research, 2016 - Elsevier
Traumatic brain injury (TBI) elicits a complex secondary injury response, with
neuroinflammation as a crucial central component. Long thought to be solely a deleterious …

Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial

CS Robertson, HJ Hannay, JM Yamal, S Gopinath… - Jama, 2014 - jamanetwork.com
Importance There is limited information about the effect of erythropoietin or a high
hemoglobin transfusion threshold after a traumatic brain injury. Objective To compare the …

Spanish Consensus Statement on alternatives to allogeneic blood transfusion: the 2013 update of the “Seville Document”

SR Leal-Noval, M Muñoz, M Asuero… - Blood …, 2013 - pmc.ncbi.nlm.nih.gov
-The use of restrictive transfusion strategies in nonbleeding, euvolaemic anaemic patients.-
Perioperative administration of tranexamic acid to patients undergoing cardiac surgery.-The …

Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin

ZZ Chong, YC Shang, S Wang, K Maiese - Progress in neurobiology, 2012 - Elsevier
Neurodegenerative disorders affect a significant portion of the world's population leading to
either disability or death for almost 30 million individuals worldwide. One novel therapeutic …

[HTML][HTML] Navigating the complexities of traumatic encephalopathy Syndrome (TES): Current state and future challenges

A Fesharaki-Zadeh - Biomedicines, 2023 - mdpi.com
Chronic traumatic encephalopathy (CTE) is a unique neurodegenerative disease that is
associated with repetitive head impacts (RHI) in both civilian and military settings. In 2014 …

2013. Documento Sevilla de Consenso sobre Alternativas a la Transfusión de Sangre Alogénica. Actualización del Documento Sevilla

SR Leal-Noval, M Muñoz, M Asuero, E Contreras… - Medicina Intensiva, 2013 - Elsevier
La transfusión de sangre alogénica (TSA) no es inocua, y como consecuencia han surgido
múltiples alternativas a la misma (ATSA). Existe variabilidad respecto a las indicaciones y …

Therapeutic effect of erythropoietin in patients with traumatic brain injury: a meta-analysis of randomized controlled trials

WC Liu, L Wen, T **e, H Wang, JB Gong… - Journal of neurosurgery, 2016 - thejns.org
OBJECTIVE Erythropoietin (EPO) exerts a neuroprotective effect in animal models of
traumatic brain injury (TBI). However, its effectiveness in human patients with TBI is unclear …

Recent developments in clinical trials for the treatment of traumatic brain injury

DG Stein, RI Geddes, EA Sribnick - Handbook of clinical neurology, 2015 - Elsevier
The clinical understanding of traumatic brain injury (TBI) and its manifestations is beginning
to change. Both clinicians and research scientists are recognizing that TBI and related …

Potential efficacy of erythropoietin on reducing the risk of mortality in patients with traumatic brain injury: a systematic review and meta‐analysis

C Liu, C Huang, J **e, H Li, M Hong… - BioMed research …, 2020 - Wiley Online Library
Objective. The objective of this study is to assess the effectiveness of erythropoietin (EPO)
on mortality, neurological outcomes, and adverse event in the treatment of traumatic brain …