Caspase-1 and the inflammasome promote polycystic kidney disease progression
KI Swenson-Fields, CJ Ward, ME Lopez… - Frontiers in molecular …, 2022 - frontiersin.org
We and others have previously shown that the presence of renal innate immune cells can
promote polycystic kidney disease (PKD) progression. In this study, we examined the …
promote polycystic kidney disease (PKD) progression. In this study, we examined the …
Emerging roles of proximal tubular endocytosis in renal fibrosis
M Chen, X Gu - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Endocytosis is a crucial component of many pathological conditions. The proximal tubules
are responsible for reabsorbing the majority of filtered water and glucose, as well as all the …
are responsible for reabsorbing the majority of filtered water and glucose, as well as all the …
A high throughput zebrafish chemical screen reveals ALK5 and non-canonical androgen signalling as modulators of the pkd2−/− phenotype
A Metzner, JD Griffiths, AJ Streets, E Markham… - Scientific reports, 2020 - nature.com
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic
cause of end-stage renal failure in humans and results from germline mutations in PKD1 or …
cause of end-stage renal failure in humans and results from germline mutations in PKD1 or …
The role of DNA damage as a therapeutic target in autosomal dominant polycystic kidney disease
JQJ Zhang, S Saravanabavan, A Munt… - Expert reviews in …, 2019 - cambridge.org
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic
kidney disease and is caused by heterozygous germ-line mutations in either PKD1 (85%) or …
kidney disease and is caused by heterozygous germ-line mutations in either PKD1 (85%) or …
Basigin Deficiency Induces Spontaneous Polycystic Kidney in Mice
F Zhong, W Li, C Zhao, L **, X Lu, Y Zhao, J Pu… - Hypertension, 2024 - Am Heart Assoc
BACKGROUND: Polycystic kidney disease is the most common hereditary kidney disorder
with early and frequent hypertension symptoms. The mechanisms of cyst progression in …
with early and frequent hypertension symptoms. The mechanisms of cyst progression in …
[HTML][HTML] Identification of key genes and candidated pathways in human autosomal dominant polycystic kidney disease by bioinformatics analysis
Background/Aims: Autosomal dominant polycystic kidney disease (ADPKD) is the most
common genetic form of kidney disease. High-throughput microarray analysis has been …
common genetic form of kidney disease. High-throughput microarray analysis has been …
Identification of ADPKD-Related Genes and Pathways in Cells Overexpressing PKD2
Z Zhang, Y Dang, Z Wang, H Wang, Y Pan, J He - Genes, 2020 - mdpi.com
Consistent with the gene dosage effect hypothesis, renal cysts can arise in transgenic
murine models overexpressing either PKD1 or PKD2, which are causal genes for autosomal …
murine models overexpressing either PKD1 or PKD2, which are causal genes for autosomal …
Identification of housekee** genes for microRNA expression analysis in kidney tissues of Pkd1 deficient mouse models
Polycystic kidney disease is a complex clinical entity which comprises a group of genetic
diseases that leads to renal cyst development. We evaluated the most suitable …
diseases that leads to renal cyst development. We evaluated the most suitable …
Metabolic reprogramming and reconstruction: Integration of experimental and computational studies to set the path forward in ADPKD
R Pagliarini, C Podrini - Frontiers in Medicine, 2021 - frontiersin.org
Metabolic reprogramming is a key feature of Autosomal Dominant Polycystic Kidney
Disease (ADPKD) characterized by changes in cellular pathways occurring in response to …
Disease (ADPKD) characterized by changes in cellular pathways occurring in response to …
Expanding the phenotypic spectrum of Mendelian connective tissue disorders to include prominent kidney phenotypes
A Strong, C Skraban, K Meyers… - American Journal of …, 2021 - Wiley Online Library
Heritable connective tissue disorders are a group of diseases, each rare, characterized by
various combinations of skin, joint, musculoskeletal, organ, and vascular involvement …
various combinations of skin, joint, musculoskeletal, organ, and vascular involvement …