Islet amyloid polypeptide: structure, function, and pathophysiology
R Akter, P Cao, H Noor, Z Ridgway… - Journal of diabetes …, 2016 - Wiley Online Library
The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose
homeostasis but aggregates to form islet amyloid in type‐2 diabetes. Islet amyloid formation …
homeostasis but aggregates to form islet amyloid in type‐2 diabetes. Islet amyloid formation …
Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis
Abstract Type 2 diabetes (T2DM) is characterized by insulin resistance, defective insulin
secretion, loss of β-cell mass with increased β-cell apoptosis and islet amyloid. The islet …
secretion, loss of β-cell mass with increased β-cell apoptosis and islet amyloid. The islet …
JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction
Inflammation is thought to underlie the pathogenesis of many chronic diseases. It is now
established that obesity results in a state of chronic low‐grade inflammation thought to …
established that obesity results in a state of chronic low‐grade inflammation thought to …
[HTML][HTML] Mechanisms of islet amyloidosis toxicity in type 2 diabetes
A Abedini, AM Schmidt - FEBS letters, 2013 - Elsevier
Amyloid formation by the neuropancreatic hormone, islet amyloid polypeptide (IAPP or
amylin), one of the most amyloidogenic sequences known, leads to islet amyloidosis in type …
amylin), one of the most amyloidogenic sequences known, leads to islet amyloidosis in type …
The β-cell assassin: IAPP cytotoxicity
Islet amyloid polypeptide (IAPP) forms cytotoxic oligomers and amyloid fibrils in islets in type
2 diabetes (T2DM). The causal factors for amyloid formation are largely unknown …
2 diabetes (T2DM). The causal factors for amyloid formation are largely unknown …
Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics
Islet amyloidosis by IAPP contributes to pancreatic β-cell death in diabetes, but the nature of
toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and …
toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and …
[HTML][HTML] Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity
P Cao, P Marek, H Noor, V Patsalo, LH Tu, H Wang… - FEBS letters, 2013 - Elsevier
Pancreatic islet amyloid is a characteristic feature of type 2 diabetes. The major protein
component of islet amyloid is the polypeptide hormone known as islet amyloid polypeptide …
component of islet amyloid is the polypeptide hormone known as islet amyloid polypeptide …
Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?
Type 2 diabetes is a progressive disease characterised by islet amyloid deposits in the
majority of patients. Amyloid formation is considered a significant factor in deterioration of …
majority of patients. Amyloid formation is considered a significant factor in deterioration of …
[HTML][HTML] IL-18 in autoimmunity
D Boraschi, CA Dinarello - European cytokine network, 2006 - jle.com
5 Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanaham TK, Zurawski G,
Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA. IL-33, an interleukin-1-like …
Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA. IL-33, an interleukin-1-like …
Islet amyloid polypeptide membrane interactions: effects of membrane composition
Amyloid formation by islet amyloid polypeptide (IAPP) contributes to β-cell dysfunction in
type 2 diabetes. Perturbation of the β-cell membrane may contribute to IAPP-induced …
type 2 diabetes. Perturbation of the β-cell membrane may contribute to IAPP-induced …