Drug-resistant tuberculosis (TB) is estimated to cause 13% of all antimicrobial resistance-
attributable deaths worldwide and is driven by both ongoing resistance acquisition and …

Tuberculosis (TB) is the number one cause of human death due to an infectious disease.
The causative agents of TB are a group of closely related bacteria known as the …

Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …

In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

Abstract Background The World Health Organization recommends drug-susceptibility testing
of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment …

To characterize the genetic determinants of resistance to antituberculosis drugs, we
performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis …

Background Diagnosing drug-resistance remains an obstacle to the elimination of
tuberculosis. Phenotypic drug-susceptibility testing is slow and expensive, and commercial …

Generalist and specialist species differ in the breadth of their ecological niches. Little is
known about the niche width of obligate human pathogens. Here we analyzed a global …

Routine full characterization of Mycobacterium tuberculosis is culture based, taking many
weeks. Whole-genome sequencing (WGS) can generate antibiotic susceptibility profiles to …