Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
RNA m6A methylation across the transcriptome
Since the early days of foundational studies of nucleic acids, many chemical moieties have
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …
Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics
Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …
mediated transcription: protein-coding transcription units and non-coding RNA transcription …
[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
RNA-mediated feedback control of transcriptional condensates
Regulation of biological processes typically incorporates mechanisms that initiate and
terminate the process and, where understood, these mechanisms often involve feedback …
terminate the process and, where understood, these mechanisms often involve feedback …
Cis-regulatory sequences in plants: their importance, discovery, and future challenges
The identification and characterization of cis-regulatory DNA sequences and how they
function to coordinate responses to developmental and environmental cues is of paramount …
function to coordinate responses to developmental and environmental cues is of paramount …
Mechanisms of enhancer action: the known and the unknown
Differential gene expression mechanisms ensure cellular differentiation and plasticity to
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …
Cellular functions of long noncoding RNAs
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …
are transcribed from the mammalian genome. They are emerging as important regulators in …
Determinants of enhancer and promoter activities of regulatory elements
The proper activities of enhancers and gene promoters are essential for coordinated
transcription within a cell. Although diverse methodologies have been developed to identify …
transcription within a cell. Although diverse methodologies have been developed to identify …
Non-coding RNAs and their integrated networks
Eukaryotic genomes are pervasively transcribed. Besides protein-coding RNAs, there are
different types of non-coding RNAs that modulate complex molecular and cellular …
different types of non-coding RNAs that modulate complex molecular and cellular …