The demand for petroleum dependent chemicals and materials has been increasing despite
the dwindling of their fossil resources. As the dead-end of petroleum based industry has …

Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …

Nanoparticle-based mRNA therapeutics hold great promise, but cellular internalization and
endosomal escape remain key barriers for cytosolic delivery. We developed a dual …

Humans are exposed to nanoscopical nanobiovectors (eg coronavirus SARS-CoV-2) as
well as abiotic metal/carbon-based nanomaterials that enter cells serendipitously or …

Understanding interactions between nanoparticles (NPs) with biological matter, particularly
cells, is becoming increasingly important due to their growing application in medicine and …

Therapeutic cancer vaccines require adjuvants leading to robust type I interferon and
proinflammatory cytokine responses in the tumor microenvironment to induce an anti-tumor …

Abstract The presence of Reactive Oxygen Species (ROS) in bone can influence resident
cells behaviour as well as the extra-cellular matrix composition and the tissue architecture …

Gene therapy uses modern molecular biology methods to repair disease‐causing genes. As
a burgeoning therapeutic, it has been widely applied for cancer therapy. Since 1989, there …

Biodegradable polymeric nanoparticles have the potential to be safer alternatives to viruses
for gene delivery; however, their use has been limited by poor efficacy in vivo. In this work …

Current glioblastoma therapies are insufficient to prevent tumor recurrence and eventual
death. Here, we describe a method to treat malignant glioma by nonviral DNA delivery using …