There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …

Aims PCSK9 is secreted into the circulation, mainly by the liver, and interacts with low-
density lipoprotein receptor (LDLR) homologous and non-homologous receptors, including …

Fatty acids are a major fuel source used to sustain contractile function in heart and oxidative
skeletal muscle. To meet the energy demands of these muscles, the uptake and β-oxidation …

The incidence of diabetes is increasing globally, with cardiovascular disease accounting for
a substantial number of diabetes-related deaths. Although atherosclerotic vascular disease …

Cellular energy homeostasis is a fundamental process that governs the overall health of the
cell and is paramount to cell survival. Central to this is the control of ATP generation and …

Obesity and diabetes are major public health problems, and are linked to the development
of heart failure. Emerging data highlight the importance of alterations in cardiac energy …

Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism and responsible for catalyzing
lipolysis of triglycerides in lipoproteins. LPL is produced mainly in adipose tissue, skeletal …

Nuclear receptors (NRs) play central roles in metabolic syndrome, making them attractive
drug targets despite the challenge of achieving functional selectivity. For instance, members …

Background The metabolic syndrome, known also as the insulin resistance syndrome, refers
to the clustering of several risk factors for atherosclerotic cardiovascular disease …