Lung cancer associated with combustion particles and fine particulate matter (PM2. 5)-The roles of polycyclic aromatic hydrocarbons (PAHs) and the aryl hydrocarbon …

JA Holme, J Vondráček, M Machala… - Biochemical …, 2023 - Elsevier
Air pollution is the leading cause of lung cancer after tobacco smoking, contributing to 20%
of all lung cancer deaths. Increased risk associated with living near trafficked roads …

[HTML][HTML] Evaluation of the cancer risk from PAHs by inhalation: Are current methods fit for purpose?

NJ Aquilina, RM Harrison - Environment international, 2023 - Elsevier
There is ample evidence from occupational studies that exposure to a mixture of Polycyclic
Aromatic Hydrocarbons (PAHs) is causally associated with an increased incidence of lung …

Wrangling whole mixtures risk assessment: recent advances in determining sufficient similarity

JE Rager, CV Rider - Current opinion in toxicology, 2023 - Elsevier
Human health risk assessments for complex mixtures can address real-world exposures and
protect public health. While risk assessors typically prefer whole mixture approaches over …

[HTML][HTML] A yearlong monitoring campaign of polycyclic aromatic compounds and other air pollutants at three sites in Sweden: source identification, in vitro toxicity and …

I Sadiktsis, MF de Oliveira Galvão, M Mustafa… - Chemosphere, 2023 - Elsevier
Air pollution is a complex mixture of gases and particulate matter (PM) with local and non-
local emission sources, resulting in spatiotemporal variability in concentrations and …

Combined exposures and mixtures research: an enduring NIEHS priority

DJ Carlin, CV Rider - Environmental Health Perspectives, 2024 - ehp.niehs.nih.gov
Background: The National Institute of Environmental Health Sciences (NIEHS) continues to
prioritize research to better understand the health effects resulting from exposure to mixtures …

[HTML][HTML] Application of an in vitro new approach methodology to determine relative cancer potency factors of air pollutants based on whole mixtures

MF de Oliveira Galvão, C Scaramboni… - Environment …, 2024 - Elsevier
Air pollution is an example of a complex environmental mixture with different biological
activities, making risk assessment challenging. Current cancer risk assessment strategies …

[HTML][HTML] Reactive oxygen species-dependent transient induction of genotoxicity by retene in human liver HepG2 cells

C Scaramboni, MLAM Campos, DJ Dorta… - Toxicology in Vitro, 2023 - Elsevier
Retene is a polycyclic aromatic hydrocarbon (PAH) emitted mainly by biomass combustion,
and despite its ubiquity in atmospheric particulate matter (PM), studies concerning its …

Pollutant-meteorological factors and cardio-respiratory mortality in Portugal: Seasonal variability and associations

ESF Duarte, PS Lucio, MJ Costa, V Salgueiro… - Environmental …, 2024 - Elsevier
Seasonal variations in cardiorespiratory diseases may be influenced by air pollution and
meteorological factors. This work aims to highlight the relevance of a complete seasonal …

[HTML][HTML] Antagonistic effects of a COX1/2 inhibitor drug in human HepG2 cells exposed to an environmental carcinogen

C Martins, MF de Oliveira Galvão, PM Costa… - Environmental …, 2024 - Elsevier
Understanding interactions between legacy and emerging environmental contaminants has
important implications for risk assessment, especially when mutagens and carcinogens are …

Diesel particulate matter aggravates cyclophosphamide-induced testicular toxicity in mice via elevating oxidative damage

WI Kim, JO Lim, SW Pak, SJ Lee, YG Yang… - Molecular & Cellular …, 2024 - Springer
Background Diesel particulate matter (DPM) induces several adverse effects on humans
upon exposure. Objectives In this study, we looked into the impact of DPM exposure on …