Computational modelling of drug delivery to solid tumour: Understanding the interplay between chemotherapeutics and biological system for optimised delivery …
Drug delivery to solid tumour involves multiple physiological, biochemical and biophysical
processes taking place across a wide range of length and time scales. The therapeutic …
processes taking place across a wide range of length and time scales. The therapeutic …
Fast porous visco-hyperelastic soft tissue model for surgery simulation: application to liver surgery
Understanding and modeling liver biomechanics represents a significant challenge due to
its complex nature. In this paper, we tackle this issue in the context of real-time surgery …
its complex nature. In this paper, we tackle this issue in the context of real-time surgery …
Using indentation to characterize the poroelasticity of gels
When an indenter is pressed into a gel to a fixed depth, the solvent in the gel migrates, and
the force on the indenter relaxes. Within the theory of poroelasticity, the force relaxation …
the force on the indenter relaxes. Within the theory of poroelasticity, the force relaxation …
On the characterization of the heterogeneous mechanical response of human brain tissue
The mechanical characterization of brain tissue is a complex task that scientists have tried to
accomplish for over 50 years. The results in the literature often differ by orders of magnitude …
accomplish for over 50 years. The results in the literature often differ by orders of magnitude …
Viscoelasticity and poroelasticity in elastomeric gels
An elastomeric gel is a mixture of a polymer network and a solvent. In response to changes
in mechanical forces and in the chemical potential of the solvent in the environment, the gel …
in mechanical forces and in the chemical potential of the solvent in the environment, the gel …
Microneedle patch capable of dual drug release for drug delivery to brain tumors
Primary brain tumors are mostly managed using surgical resection procedures.
Nevertheless, in certain cases, a thin layer of tumors may remain outside of the resection …
Nevertheless, in certain cases, a thin layer of tumors may remain outside of the resection …
Spatiotemporal multi-scale modeling of radiopharmaceutical distributions in vascularized solid tumors
We present comprehensive mathematical modeling of radiopharmaceutical spatiotemporal
distributions within vascularized solid tumors. The novelty of the presented model is at …
distributions within vascularized solid tumors. The novelty of the presented model is at …
Distinguishing poroelasticity and viscoelasticity of brain tissue with time scale
L Su, M Wang, J Yin, F Ti, J Yang, C Ma, S Liu, TJ Lu - Acta Biomaterialia, 2023 - Elsevier
Brain tissue is considered to be biphasic, with approximately 80% liquid and 20% solid
matrix, thus exhibiting viscoelasticity due to rearrangement of the solid matrix and …
matrix, thus exhibiting viscoelasticity due to rearrangement of the solid matrix and …
Efficient drug delivery to hypoxic tumors using thermosensitive liposomes with encapsulated anti-cancer drug under high intensity pulsed ultrasound
Poor half-life, short circulation, systemic toxicity, insufficient accumulation, and ultimately
weak therapeutic response are the most important obstacles in the conventional …
weak therapeutic response are the most important obstacles in the conventional …
Analysis of magneto-hyperthermia duration in nano-sized drug delivery system to solid tumors using intravascular-triggered thermosensitive-liposome
Computational models have been developed as a potential platform to identify bio-
interactions that cannot be properly understood by experimental models. In the present …
interactions that cannot be properly understood by experimental models. In the present …