Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional
groups to explore and understand biology in living organisms. In this review, we summarize …

Designing simple biomaterials to replicate the biochemical and mechanical properties of
tissues is an ongoing challenge in tissue engineering. For several decades, new …

Many successful stories in enzyme engineering are based on the creation of randomized
diversity in large mutant libraries, containing millions to billions of enzyme variants. Methods …

The development of next generation soft and recyclable materials prominently features
dynamic (reversible) chemistries such as host–guest, supramolecular, and dynamic …

Hydrazone and oxime bond formation between α-nucleophiles (eg hydrazines, alkoxy-
amines) and carbonyl compounds (aldehydes and ketones) is convenient and is widely …

Bean aphid (Aphis craccivora) resistance to commonly used insecticides has made
controlling these pests increasingly difficult. In this study, we introduced isoxazole and …

Proteolytic cleavage of cell surface proteins triggers critical processes including cell–cell
interactions, receptor activation, and shedding of signaling proteins. Consequently …

Two visible-light-mediated O–H insertion protocols involving oximes and aryldiazoacetates
leading to different products depending on the solvent employed are reported. In DCM …

We describe the fast reaction kinetics between 1, 2-aminothiols and aldehydes. Under
physiological conditions such a click-type reaction afforded a thiazolidine product that …

Acylhydrazones formation has been widely applied in materials science and biolabeling.
However, their sluggish condensation rate under neutral conditions limits its application …