Chronic diabetic wounds represent a huge socioeconomic burden for both affected
individuals and the entire healthcare system. Although the number of available treatment …

Macrophages and endothelial cells (ECs) have essential roles in physiological and
pathological conditions by regulating inflammation, vascularization and tissue remodelling …

In this study, a new type of biodegradable, injectable, self-healing, and low-toxic CMCSH,
formed by N, O-carboxymethyl chitosan-heparin (CMCS-Hep) and carboxymethyl cellulose …

Injectable hydrogels with the capability to cast a hypoxic microenvironment is of great
potentialities to develop novel therapies for tissue regeneration. However, the relative …

Mesenchymal stem cells (MSCs) have been increasingly recognized as a resource for
disease treatment and regenerative medicine. Meanwhile, the unique chemical and physical …

Transplantation of progenitor cells can accelerate tissue healing and regenerative
processes. Nonetheless, direct cell delivery fails to support survival of transplanted cells or …

Oxygen plays a critical role as a substrate for metabolism and as a signaling molecule
regulating cellular activities. In particular, hyperbaric oxygen has been demonstrated to …

Although alginate-based hydrogels have been widely used as injectable matrices in a wide
range of biomedical applications because of their biocompatibility and easy fabrication …

Skin indicates a person's state of health and is so important that it influences a person's
emotional and psychological behavior. In this context, the effective treatment of wounds is a …

The unique physiochemical properties and the porous network architecture of hydrogel seek
the attention to be explored in broad range of fields. In the last decade, numerous studies on …