Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Histone deacetylases (HDACs)—enzymes that affect the acetylation status of histones and
other important cellular proteins—have been recognized as potentially useful therapeutic …

Epigenetic mechanisms control various functions throughout the body, from cell fate
determination in development to immune responses and inflammation. Neuroinflammation …

Epigenetic modifications help orchestrate swee** developmental, aging, and disease-
causing changes in phenotype by altering transcriptional activity in multiple genes spanning …

Epigenetics and epigenomic medicine encompass a new science of brain and behavior that
are already providing unique insights into the mechanisms underlying brain development …

Amyotrophic lateral sclerosis (ALS) is a terminal disease involving the progressive
degeneration of motor neurons within the motor cortex, brainstem and spinal cord. Most …

Phenotypic diversity is shaped by both genetic and epigenetic mechanisms that program
tissue specific patterns of gene expression. Cells, including neurons, undergo massive …

Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease characterized
with autoimmune response against myelin proteins and progressive axonal loss. The …

Lysine acetylation is becoming increasingly appreciated as a key post-translational
modification in the endogenous regulation of protein function. The so-called histone acetyl …

Epigenetic enzymes histone deacetylases (HDACs) are clinically validated anticancer drug
targets which have been studied intensively in the past few decades. Although several drugs …