Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the
post-transcriptional process that profoundly impact protein production in a cell. While it is …

Transfer RNAs (tRNAs) have a crucial role in protein synthesis, and in recent years, their
therapeutic potential for the treatment of genetic diseases—primarily those associated with a …

Abstract tRNAscan-SE has been widely used for transfer RNA (tRNA) gene prediction for
over twenty years, developed just as the first genomes were decoded. With the massive …

Transfer RNAs are essential for translating genetic information into proteins. The human
genome contains hundreds of predicted tRNA genes, many in multiple copies. How their …

Here, we report the design, construction, and characterization of a tRNA neochromosome, a
designer chromosome that functions as an additional, de novo counterpart to the native …

Transfer ribonucleic acid (tRNA) therapeutics will provide personalized and mutation
specific medicines to treat human genetic diseases for which no cures currently exist. The …

Recent investigations on the non-protein-coding transcriptome of human cells have
revealed previously hidden layers of gene regulation relying on regulatory non-protein …

Metazoan organisms have many tRNA genes responsible for decoding amino acids. The set
of all tRNA genes can be grouped in sets of common amino acids and isoacceptor tRNAs …

By linking amino acids to their codon assignments, transfer RNAs (tRNAs) are essential for
protein synthesis and translation fidelity. Some human tRNA variants cause amino acid mis …

Endogenous transfer RNA‐derived small RNAs (tsRNAs) are newly identified RNAs that are
closely associated with the pathogenesis of multiple diseases, but the involvement of …