The late 1990s were banner years in molecular neuroscience; seminal studies
demonstrated that local protein synthesis, at or near synapses, was necessary for synaptic …

Growing evidence exposes translation and its translational machinery as key players in
establishing and maintaining physiological and pathological biological processes …

Efficiently delivering exogenous materials into primary neurons and neural stem cells
(NSCs) has long been a challenge in neurobiology. Existing methods have struggled with …

The tumor suppressor p53 transactivates the expression of multiple genes to exert its
multifaceted functions and ultimately maintains genome stability. Thus, cancer cells develop …

Objective Brown adipose tissue (BAT) plays an important role in mammalian thermogenesis
through the expression of uncoupling protein 1 (UCP1). Our previous study identified …

Simple Summary Near-infrared imaging of tumors during surgery facilitates the oncologic
surgeon to distinguish malignant from healthy tissue. The technique is based on fluorescent …

Background Local translation at synapses is important for rapidly remodeling the synaptic
proteome to sustain long-term plasticity and memory. While the regulatory mechanisms …

Aims Trophoblast cell dysfunction is one of the important factors leading to preeclampsia
(PE). Cytoplasmic polyadenylation element-binding 2 (CPEB2) has been found to be …

Features encoded in the mRNA contribute substantially to the translation efficiency of a
transcript. After processing of the 5'and 3'end and export of the mRNA to the cytoplasm …