Background: From a therapeutic viewpoint, understanding how drugs bind and regulate the
functions of their target proteins to protect against disease is crucial. The identification of …

Background Metabolites disrupted by abnormal state of human body are deemed as the
effect of diseases. In comparison with the cause of diseases like genes, these markers are …

Background. Herba Siegesbeckiae (HS, **xiancao in Chinese) is widely used to treat
inflammatory joint diseases such as rheumatoid arthritis (RA) and arthritis, and its molecular …

Background Single cell RNA sequencing (scRNA-seq) is applied to assay the individual
transcriptomes of large numbers of cells. The gene expression at single-cell level provides …

OAHG, an integrated resource, aims to establish a comprehensive functional annotation
resource for human protein-coding genes (PCGs), miRNAs, and lncRNAs by multi-level …

Abstract Background The Gene Ontology (GO) is a community-based bioinformatics
resource that employs ontologies to represent biological knowledge and describes …

Abstract Background Gene Ontology (GO) is one of the most popular bioinformatics
resources. In the past decade, Gene Ontology-based gene semantic similarity has been …

Background Similar diseases are always caused by similar molecular origins, such as
diasease-related protein-coding genes (PCGs). And the molecular associations reflect their …

Background Identifying the genes associated to human diseases is crucial for disease
diagnosis and drug design. Computational approaches, esp. the network-based …

It is critical yet remains to be challenging to make precise disease diagnosis from complex
clinical features and highly heterogeneous genetic background. Recently, phenotype …