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The Hippo signalling pathway and its implications in human health and diseases
As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …
the regulation of numerous biological processes. Thus, substantial efforts have been made …
The Hippo signaling pathway in development and regeneration
The Hippo signaling pathway is a central growth control mechanism in multicellular
organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo …
organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo …
Mechanoregulation of YAP and TAZ in cellular homeostasis and disease progression
Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …
homeostasis. During organ development and tissue injury repair, compressive and tensional …
The Hippo pathway: biology and pathophysiology
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …
Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …
YAP/TAZ upstream signals and downstream responses
A Totaro, T Panciera, S Piccolo - Nature cell biology, 2018 - nature.com
Cell behaviour is strongly influenced by physical, mechanical contacts between cells and
their extracellular matrix. We review how the transcriptional regulators YAP and TAZ …
their extracellular matrix. We review how the transcriptional regulators YAP and TAZ …
The Hippo signaling pathway in development and disease
The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …
has been implicated in an increasing number of human diseases, including cancer. Here …
YAP/TAZ at the roots of cancer
F Zanconato, M Cordenonsi, S Piccolo - Cancer cell, 2016 - cell.com
YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …
The Hippo signaling network and its biological functions
Hippo signaling is an evolutionarily conserved network that has a central role in regulating
cell proliferation and cell fate to control organ growth and regeneration. It promotes …
cell proliferation and cell fate to control organ growth and regeneration. It promotes …
Hippo pathway in organ size control, tissue homeostasis, and cancer
Two decades of studies in multiple model organisms have established the Hippo pathway
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …