Understanding how gut flora influences gut-brain communications has been the subject of
significant research over the past decade. The broadening of the term “microbiota-gut-brain …

Recent advances suggest that the response of RNA metabolism to stress has an important
role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral …

Tau (MAPT) drives neuronal dysfunction in Alzheimer disease (AD) and other tauopathies.
To dissect the underlying mechanisms, we combined an engineered ascorbic acid …

Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …

Formation of membrane-less organelles via liquid-liquid phase separation is one way cells
meet the biological requirement for spatiotemporal regulation of cellular components and …

The transition between soluble intrinsically disordered tau protein and aggregated tau in
neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau …

Aggregation of the microtubule-associated protein tau plays a major role in Alzheimer's
disease and several other neurodegenerative disorders. An exciting recent development is …

Neurodegenerative diseases cause progressive loss of cognitive and/or motor function and
pose major challenges for societies with rapidly aging populations. Human genetics studies …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …