Genome-wide association studies (GWASs) have focused primarily on populations of
European descent, but it is essential that diverse populations become better represented …

Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate
the genetic architecture and biology of heart, lung, blood and sleep disorders, with the …

High-coverage whole-genome sequence studies have so far focused on a limited number of
geographically restricted populations,,,, or been targeted at specific diseases, such as …

The human proteome is a crucial intermediate between complex diseases and their genetic
and environmental components, and an important source of drug development targets and …

Most genome-wide association studies are based on samples of European descent. We
assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor …

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between
individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive …

As a scientific community we assumed that exome sequencing will elucidate the basis of
most heritable diseases. However, it turned out it was not the case; therefore, attention has …

Genome-wide association studies (GWAS) have identified associations between thousands
of common genetic variants and human traits. However, common variants usually explain a …

Motivation Very low-depth sequencing has been proposed as a cost-effective approach to
capture low-frequency and rare variation in complex trait association studies. However, a full …

Background Low-frequency variants play an important role in breast cancer (BC)
susceptibility. Gene-based methods can increase power by combining multiple variants in …