Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes
Type 2 diabetes is caused by insulin resistance coupled with an inability to produce enough
insulin to control blood glucose, and thiazolidinediones (TZDs) are the only current …
insulin to control blood glucose, and thiazolidinediones (TZDs) are the only current …
Functional regulation of PPARs through post-translational modifications
R Brunmeir, F Xu - International journal of molecular sciences, 2018 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor
superfamily and they are essential regulators of cell differentiation, tissue development, and …
superfamily and they are essential regulators of cell differentiation, tissue development, and …
Transcriptional regulation of adipogenesis
PM de Sá, AJ Richard, H Hang… - Comprehensive …, 2011 - Wiley Online Library
Adipocytes are the defining cell type of adipose tissue. Once considered a passive
participant in energy storage, adipose tissue is now recognized as a dynamic organ that …
participant in energy storage, adipose tissue is now recognized as a dynamic organ that …
PPARγ signaling and emerging opportunities for improved therapeutics
S Wang, EJ Dougherty, RL Danner - Pharmacological Research, 2016 - Elsevier
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated nuclear
receptor that regulates glucose and lipid metabolism, endothelial function and inflammation …
receptor that regulates glucose and lipid metabolism, endothelial function and inflammation …
The impact of molecular dynamics on drug design: applications for the characterization of ligand–macromolecule complexes
Highlights•Which molecular dynamics (MD) techniques are available for drug design?•How
is MD used to investigate ligand–macromolecule complexes?•How are MD studies applied …
is MD used to investigate ligand–macromolecule complexes?•How are MD studies applied …
Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism
AJ Kroker, JB Bruning - PPAR research, 2015 - Wiley Online Library
PPARγ (peroxisome proliferator activated receptor γ) is a ligand activated transcription factor
of the nuclear receptor superfamily that controls the expression of a variety of genes …
of the nuclear receptor superfamily that controls the expression of a variety of genes …
The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes
A promising approach for treating type 2 diabetes mellitus (T2DM) is to target the
Peroxisome Proliferator-Activated Receptor γ (PPARγ) transcription factor, which regulates …
Peroxisome Proliferator-Activated Receptor γ (PPARγ) transcription factor, which regulates …
Obesity-linked PPARγ S273 phosphorylation promotes insulin resistance through growth differentiation factor 3
The thiazolidinediones (TZDs) are ligands of PPARγ that improve insulin sensitivity, but their
use is limited by significant side effects. Recently, we demonstrated a mechanism wherein …
use is limited by significant side effects. Recently, we demonstrated a mechanism wherein …
Novel thiazolidin-4-one benzenesulfonamide hybrids as PPARγ agonists: Design, synthesis and in vivo anti-diabetic evaluation
IH Ali, RM Hassan, AM El Kerdawy… - European Journal of …, 2024 - Elsevier
In the current study, two series of novel thiazolidin-4-one benzenesulfonamide arylidene
hybrids 9a-l and 10a-f were designed, synthesized and tested in vitro for their PPARɣ …
hybrids 9a-l and 10a-f were designed, synthesized and tested in vitro for their PPARɣ …
[HTML][HTML] Design, synthesis, characterization and Antidiabetic evaluation of 3, 5-substituted thiazolidinediones: Evidenced by network pharmacology, Molecular docking …
S Gharge, SG Alegaon, S Jadhav, SD Ranade… - European Journal of …, 2024 - Elsevier
In search of new antidiabetic agents, heterocyclic compounds containing 3, 5-Substituted
thiazolidinedione moieties were synthesized through a concise three-step reaction process …
thiazolidinedione moieties were synthesized through a concise three-step reaction process …