Abstract Human papillomavirus (HPV)-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …

Most head and neck cancers are derived from the mucosal epithelium in the oral cavity,
pharynx and larynx and are known collectively as head and neck squamous cell carcinoma …

Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB): E2F
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …

Human malignancies arise predominantly in tissues of epithelial origin, where the stepwise
transformation from healthy epithelium to premalignant dysplasia to invasive neoplasia …

Ki-67 serves as a prominent cancer marker. We describe how expression of the MKI67 gene
coding for Ki-67 is controlled during the cell cycle. MKI67 mRNA and Ki-67 protein are …

Persistent human papillomavirus (HPV) infection is recognized as the main cause of cervical
cancer and other malignant cancers. Although early detection and treatment can be …

Activation of the p53 tumor suppressor can lead to cell cycle arrest. The key mechanism of
p53-mediated arrest is transcriptional downregulation of many cell cycle genes. In recent …

Cervical cancer is the third most common cancer in women worldwide, with concepts and
knowledge about its prevention and treatment evolving rapidly. Human papillomavirus …

HPVs (human papillomaviruses) infect epithelial cells and their replication cycle is intimately
linked to epithelial differentiation. There are over 200 different HPV genotypes identified to …

Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …