Repair pathway choices and consequences at the double-strand break
DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity.
Failure to repair a DSB has deleterious consequences, including genomic instability and cell …
Failure to repair a DSB has deleterious consequences, including genomic instability and cell …
[Retracted] Apoptosis and Molecular Targeting Therapy in Cancer
M Hassan, H Watari, A AbuAlmaaty… - BioMed research …, 2014 - Wiley Online Library
Apoptosis is the programmed cell death which maintains the healthy survival/death balance
in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced …
in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced …
DNA double-strand breaks: signaling, repair and the cancer connection
To ensure the high-fidelity transmission of genetic information, cells have evolved
mechanisms to monitor genome integrity. Cells respond to DNA damage by activating a …
mechanisms to monitor genome integrity. Cells respond to DNA damage by activating a …
Double-strand break end resection and repair pathway choice
LS Symington, J Gautier - Annual review of genetics, 2011 - annualreviews.org
DNA double-strand breaks (DSBs) are cytotoxic lesions that can result in mutagenic events
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for …
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for …
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
JR Walker, RA Corpina, J Goldberg - Nature, 2001 - nature.com
Abstract The Ku heterodimer (Ku70 and Ku80 subunits) contributes to genomic integrity
through its ability to bind DNA double-strand breaks and facilitate repair by the non …
through its ability to bind DNA double-strand breaks and facilitate repair by the non …
DNA repair mechanisms in dividing and non-dividing cells
T Iyama, DM Wilson III - DNA repair, 2013 - Elsevier
DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple
forms, and if allowed to persist, can promote genome instability and directly lead to various …
forms, and if allowed to persist, can promote genome instability and directly lead to various …
Sensing and repairing DNA double-strand breaks
SP Jackson - Carcinogenesis, 2002 - academic.oup.com
The DNA double-strand break (DSB) is the principle cytotoxic lesion for ionizing radiation
and radio-mimetic chemicals but can also be caused by mechanical stress on chromosomes …
and radio-mimetic chemicals but can also be caused by mechanical stress on chromosomes …
Genomic instability in mice lacking histone H2AX
A Celeste, S Petersen, PJ Romanienko… - Science, 2002 - science.org
Higher order chromatin structure presents a barrier to the recognition and repair of DNA
damage. Double-strand breaks (DSBs) induce histone H2AX phosphorylation, which is …
damage. Double-strand breaks (DSBs) induce histone H2AX phosphorylation, which is …
[HTML][HTML] DNA double strand break repair via non-homologous end-joining
AJ Davis, DJ Chen - Translational cancer research, 2013 - ncbi.nlm.nih.gov
DNA double-stranded breaks (DSB) are among the most dangerous forms of DNA damage.
Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis …
Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis …
Chromosomal stability and the DNA double-stranded break connection
Genome stability is of primary importance for the survival and proper functioning of all
organisms. Double-stranded breaks in DNA are important threats to genome integrity …
organisms. Double-stranded breaks in DNA are important threats to genome integrity …