Integrating mechanism-based modeling with biomedical imaging to build practical digital twins for clinical oncology

C Wu, G Lorenzo, DA Hormuth, EABF Lima… - Biophysics …, 2022 - pubs.aip.org
Digital twins employ mathematical and computational models to virtually represent a
physical object (eg, planes and human organs), predict the behavior of the object, and …

Preclinical models for drug discovery for metastatic disease

L Wakefield, S Agarwal, K Tanner - Cell, 2023 - cell.com
Despite many advances, metastatic disease remains essentially uncurable. Thus, there is an
urgent need to better understand mechanisms that promote metastasis, drive tumor …

Deconvolution of clinical variance in CAR-T cell pharmacology and response

DC Kirouac, C Zmurchok, A Deyati, J Sicherman… - Nature …, 2023 - nature.com
Chimeric antigen receptor T cell (CAR-T) expansion and persistence vary widely among
patients and predict both efficacy and toxicity. However, the mechanisms underlying clinical …

Combining microenvironment normalization strategies to improve cancer immunotherapy

F Mpekris, C Voutouri, JW Baish, DG Duda… - Proceedings of the …, 2020 - pnas.org
Advances in immunotherapy have revolutionized the treatment of multiple cancers.
Unfortunately, tumors usually have impaired blood perfusion, which limits the delivery of …

Mathematical modeling of cancer immunotherapy for personalized clinical translation

JD Butner, P Dogra, C Chung, R Pasqualini… - Nature computational …, 2022 - nature.com
Encouraging advances are being made in cancer immunotherapy modeling, especially in
the key areas of develo** personalized treatment strategies based on individual patient …

[HTML][HTML] Mathematical modeling of radiotherapy and its impact on tumor interactions with the immune system

RA Bekker, S Kim, S Pilon-Thomas, H Enderling - Neoplasia, 2022 - Elsevier
Radiotherapy is a primary therapeutic modality widely utilized with curative intent.
Traditionally tumor response was hypothesized to be due to high levels of cell death …

[HTML][HTML] An overview of mathematical modelling in cancer research: fractional calculus as modelling tool

LC Vieira, RS Costa, D Valério - Fractal and fractional, 2023 - mdpi.com
Cancer is a complex disease, responsible for a significant portion of global deaths. The
increasing prioritisation of know-why over know-how approaches in biological research has …

[HTML][HTML] A new approach using integral transform to solve cancer models

R Saadeh, A Qazza, K Amawi - Fractal and Fractional, 2022 - mdpi.com
The objective of this work is to investigate analytical solutions of some models of cancer
tumors using the Laplace residual power series method (LRPSM). The proposed method …

[HTML][HTML] Cancer modeling: From mechanistic to data-driven approaches, and from fundamental insights to clinical applications

S Bekisz, L Geris - Journal of Computational Science, 2020 - Elsevier
Cancer is still one of the major causes of death worldwide. Even if its comprehension is
improving continuously, the complexity and heterogeneity of this group of diseases …

A comprehensive review of computational cell cycle models in guiding cancer treatment strategies

C Ma, E Gurkan-Cavusoglu - NPJ Systems Biology and Applications, 2024 - nature.com
This article reviews the current knowledge and recent advancements in computational
modeling of the cell cycle. It offers a comparative analysis of various modeling paradigms …