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Integrating mechanism-based modeling with biomedical imaging to build practical digital twins for clinical oncology
Digital twins employ mathematical and computational models to virtually represent a
physical object (eg, planes and human organs), predict the behavior of the object, and …
physical object (eg, planes and human organs), predict the behavior of the object, and …
Preclinical models for drug discovery for metastatic disease
Despite many advances, metastatic disease remains essentially uncurable. Thus, there is an
urgent need to better understand mechanisms that promote metastasis, drive tumor …
urgent need to better understand mechanisms that promote metastasis, drive tumor …
Deconvolution of clinical variance in CAR-T cell pharmacology and response
Chimeric antigen receptor T cell (CAR-T) expansion and persistence vary widely among
patients and predict both efficacy and toxicity. However, the mechanisms underlying clinical …
patients and predict both efficacy and toxicity. However, the mechanisms underlying clinical …
Combining microenvironment normalization strategies to improve cancer immunotherapy
Advances in immunotherapy have revolutionized the treatment of multiple cancers.
Unfortunately, tumors usually have impaired blood perfusion, which limits the delivery of …
Unfortunately, tumors usually have impaired blood perfusion, which limits the delivery of …
Mathematical modeling of cancer immunotherapy for personalized clinical translation
Encouraging advances are being made in cancer immunotherapy modeling, especially in
the key areas of develo** personalized treatment strategies based on individual patient …
the key areas of develo** personalized treatment strategies based on individual patient …
[HTML][HTML] Mathematical modeling of radiotherapy and its impact on tumor interactions with the immune system
Radiotherapy is a primary therapeutic modality widely utilized with curative intent.
Traditionally tumor response was hypothesized to be due to high levels of cell death …
Traditionally tumor response was hypothesized to be due to high levels of cell death …
[HTML][HTML] An overview of mathematical modelling in cancer research: fractional calculus as modelling tool
LC Vieira, RS Costa, D Valério - Fractal and fractional, 2023 - mdpi.com
Cancer is a complex disease, responsible for a significant portion of global deaths. The
increasing prioritisation of know-why over know-how approaches in biological research has …
increasing prioritisation of know-why over know-how approaches in biological research has …
[HTML][HTML] A new approach using integral transform to solve cancer models
The objective of this work is to investigate analytical solutions of some models of cancer
tumors using the Laplace residual power series method (LRPSM). The proposed method …
tumors using the Laplace residual power series method (LRPSM). The proposed method …
[HTML][HTML] Cancer modeling: From mechanistic to data-driven approaches, and from fundamental insights to clinical applications
Cancer is still one of the major causes of death worldwide. Even if its comprehension is
improving continuously, the complexity and heterogeneity of this group of diseases …
improving continuously, the complexity and heterogeneity of this group of diseases …
A comprehensive review of computational cell cycle models in guiding cancer treatment strategies
C Ma, E Gurkan-Cavusoglu - NPJ Systems Biology and Applications, 2024 - nature.com
This article reviews the current knowledge and recent advancements in computational
modeling of the cell cycle. It offers a comparative analysis of various modeling paradigms …
modeling of the cell cycle. It offers a comparative analysis of various modeling paradigms …