Abstract In 2011, the National Institute on Aging and Alzheimer's Association created
separate diagnostic recommendations for the preclinical, mild cognitive impairment, and …

FreeSurfer is a suite of tools for the analysis of neuroimaging data that provides an array of
algorithms to quantify the functional, connectional and structural properties of the human …

Antiamyloid antibodies have been used to reduce cerebral amyloid-beta (Aβ) load in
patients with Alzheimer's disease. We applied focused ultrasound with each of six monthly …

The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years
before the diagnosis of AD dementia. This long “preclinical” phase of AD would provide a …

The neuropathological hallmarks of Alzheimer disease (AD) include “positive” lesions such
as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial …

Delirium and dementia are two frequent causes of cognitive impairment among older adults
and have a distinct, complex and interconnected relationship. Delirium is an acute …

Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …

Thanks to its safety and accessibility, magnetic resonance imaging (MRI) is extensively used
in clinical routine and research field, largely contributing to our understanding of the …

As medical imaging enters its information era and presents rapidly increasing needs for big
data analytics, robust pooling and harmonization of imaging data across diverse cohorts …

Neuroimaging has made it possible to measure pathological brain changes associated with
Alzheimer's disease (AD) in vivo. Over the past decade, these measures have been …