Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory
hubs for a variety of signal transduction pathways. Despite having a conserved basic …

Morphological asymmetry is a common feature of animal body plans, from shell coiling in
snails to organ placement in humans. The signaling protein Nodal is key for determining this …

Normal tables of development are essential for studies of embryogenesis, serving as an
important resource for model organisms, including the frog Xenopus laevis. Xenopus has …

Abstract The mir-34/449 family consists of six homologous miRNAs at three genomic loci.
Redundancy of miR-34/449 miRNAs and their dominant expression in multiciliated epithelia …

Transitioning from pluripotency to differentiated cell fates is fundamental to both embryonic
development and adult tissue homeostasis. Improving our understanding of this transition …

Heterotaxy is a disorder of left–right body patterning, or laterality, that is associated with
major congenital heart disease. The aetiology and mechanisms underlying most cases of …

Understanding how and when the left–right (LR) axis is first established is a fundamental
question in developmental biology. A popular model is that the LR axis is established …

Primary cilia project from the surface of most vertebrate cells and are key in sensing
extracellular signals and locally transducing this information into a cellular response. Recent …

WNT signaling is important in development, stem cell maintenance, and disease. WNT
ligands typically signal via receptor activation across the plasma membrane to induce β …

Cilia and Wnt signaling have a complex relationship, wherein Wnt regulates cilia and,
conversely, cilia may affect Wnt signaling. Recently, it was shown that Wnt receptors are …