Ecology and evolution of Mycobacterium tuberculosis

S Gagneux - Nature Reviews Microbiology, 2018 - nature.com
Tuberculosis (TB) is the number one cause of human death due to an infectious disease.
The causative agents of TB are a group of closely related bacteria known as the …

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

K Dheda, T Gumbo, G Maartens, KE Dooley… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives

SM Gygli, S Borrell, A Trauner… - FEMS microbiology …, 2017 - academic.oup.com
Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …

Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection

JD Simmons, CM Stein, C Seshadri, M Campo… - Nature Reviews …, 2018 - nature.com
Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a
long-lived latent infection in a substantial proportion of the human population. Multiple lines …

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

D Stucki, D Brites, L Jeljeli, M Coscolla, Q Liu… - Nature …, 2016 - nature.com
Generalist and specialist species differ in the breadth of their ecological niches. Little is
known about the niche width of obligate human pathogens. Here we analyzed a global …

Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs

JE Phelan, DM O'Sullivan, D Machado, J Ramos… - Genome medicine, 2019 - Springer
Background Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major
threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction …

[HTML][HTML] Human tuberculosis and Mycobacterium tuberculosis complex: A review on genetic diversity, pathogenesis and omics approaches in host biomarkers …

RD Kanabalan, LJ Lee, TY Lee, PP Chong… - Microbiological …, 2021 - Elsevier
Mycobacterium tuberculosis complex (MTBC) refers to a group of mycobacteria
encompassing nine members of closely related species that causes tuberculosis in animals …

Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues

CJ Meehan, GA Goig, TA Kohl, L Verboven… - NATURE reviews …, 2019 - nature.com
Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed
from a research tool to a clinical application for the diagnosis and management of …

MTBseq: a comprehensive pipeline for whole genome sequence analysis of Mycobacterium tuberculosis complex isolates

TA Kohl, C Utpatel, V Schleusener, MR De Filippo… - PeerJ, 2018 - peerj.com
Analyzing whole-genome sequencing data of Mycobacterium tuberculosis complex (MTBC)
isolates in a standardized workflow enables both comprehensive antibiotic resistance …