Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …

Pneumonia is inflammation in the lungs, which is usually caused by an infection. The
symptoms of pneumonia can vary from mild to life-threatening, where severe illness is often …

Influenza A virus (IAV) infection mobilizes bone marrow-derived macrophages (BMDM) that
gradually undergo transition to tissue-resident alveolar macrophages (TR-AM) in the …

Background Abnormal macrophage function caused by dysfunctional cystic fibrosis
transmembrane conductance regulator (CFTR) is a critical contributor to chronic airway …

Precision management of fibrotic lung diseases is challenging due to their diverse clinical
trajectories and lack of reliable biomarkers for risk stratification and therapeutic monitoring …

Alveolar macrophages (AMs) reside on the luminal surface of the airways and alveoli,
ensuring proper gas exchange by ingesting cellular debris and pathogens, and regulating …

Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS),
present life-threatening conditions characterized by inflammation and endothelial injury …

Resolving inflammation is thought to return the affected tissue back to homoeostasis but
recent evidence supports a non-linear model of resolution involving a phase of prolonged …

Macrophages are the primary host cell type for infection by Mycobacterium tuberculosis in
vivo. Macrophages are also key immune effector cells that mediate the control of bacterial …

Respiratory infections and especially viral infections, along with other extrinsic
environmental factors, have been shown to profoundly affect macrophage populations in the …