Improved tools to study astrocytes

X Yu, J Nagai, BS Khakh - Nature Reviews Neuroscience, 2020 - nature.com
Astrocytes are a type of glial cell that tile the CNS. They interact with multiple cell types,
including neurons, glial cells and blood vessels, and are involved or implicated in brain …

Astrocyte-neuron signaling in synaptogenesis

L Shan, T Zhang, K Fan, W Cai, H Liu - Frontiers in cell and …, 2021 - frontiersin.org
Astrocytes are the key component of the central nervous system (CNS), serving as pivotal
regulators of neuronal synapse formation and maturation through their ability to dynamically …

Microglial calcium signaling is attuned to neuronal activity in awake mice

AD Umpierre, LL Bystrom, Y Ying, YU Liu, G Worrell… - Elife, 2020 - elifesciences.org
Microglial calcium signaling underlies a number of key physiological and pathological
processes in situ, but has not been studied in vivo in awake mice. Using multiple GCaMP6 …

Calcium signaling in neuroglia

D Lim, A Semyanov, A Genazzani… - International review of cell …, 2021 - Elsevier
Glial cells exploit calcium (Ca 2+) signals to perceive the information about the activity of the
nervous tissue and the tissue environment to translate this information into an array of …

Computational models for calcium-mediated astrocyte functions

T Manninen, R Havela, ML Linne - Frontiers in computational …, 2018 - frontiersin.org
The computational neuroscience field has heavily concentrated on the modeling of neuronal
functions, largely ignoring other brain cells, including one type of glial cell, the astrocytes …

Local and CNS-wide astrocyte intracellular calcium signaling attenuation in vivo with CalExflox mice

X Yu, SL Moye, BS Khakh - Journal of Neuroscience, 2021 - Soc Neuroscience
Astrocytes exist throughout the CNS and affect neural circuits and behavior through
intracellular Ca2+ signaling. Studying the function (s) of astrocyte Ca2+ signaling has …

Analysis of network models with neuron-astrocyte interactions

T Manninen, J Aćimović, ML Linne - Neuroinformatics, 2023 - Springer
Neural networks, composed of many neurons and governed by complex interactions
between them, are a widely accepted formalism for modeling and exploring global dynamics …

Astrocytes exhibit diverse Ca2+ changes at subcellular domains during brain aging

F Ding, S Liang, R Li, Z Yang, Y He, S Yang… - Frontiers in Aging …, 2022 - frontiersin.org
Astrocytic Ca2+ transients are essential for astrocyte integration into neural circuits. These
Ca2+ transients are primarily sequestered in subcellular domains, including primary …

Advances in astrocyte computational models: from metabolic reconstructions to multi-omic approaches

J González, A Pinzón, A Angarita-Rodríguez… - Frontiers in …, 2020 - frontiersin.org
The growing importance of astrocytes in the field of neuroscience has led to a greater
number of computational models devoted to the study of astrocytic functions and their …

Unraveling Aβ-mediated multi-pathway calcium dynamics in astrocytes: Implications for Alzheimer's disease treatment from simulations

L Liu, H Gao, A Zaikin, S Chen - Frontiers in physiology, 2021 - frontiersin.org
The accumulation of amyloid β peptide (Aβ) in the brain is hypothesized to be the major
factor driving Alzheimer's disease (AD) pathogenesis. Mounting evidence suggests that …