Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Electrostatic interactions in protein structure, folding, binding, and condensation
Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less
specific electrostatic interactions, impart important properties to proteins. Modulation of the …
specific electrostatic interactions, impart important properties to proteins. Modulation of the …
Sequence determinants of the conformational properties of an intrinsically disordered protein prior to and upon multisite phosphorylation
Many cell signaling events are coordinated by intrinsically disordered protein regions (IDRs)
that undergo multisite Serine/Threonine phosphorylation. The conformational properties of …
that undergo multisite Serine/Threonine phosphorylation. The conformational properties of …
Differential solvation of intrinsically disordered linkers drives the formation of spatially organized droplets in ternary systems of linear multivalent proteins
Intracellular biomolecular condensates are membraneless organelles that encompass large
numbers of multivalent protein and nucleic acid molecules. The bodies assemble via a …
numbers of multivalent protein and nucleic acid molecules. The bodies assemble via a …
Full structural ensembles of intrinsically disordered proteins from unbiased molecular dynamics simulations
Molecular dynamics (MD) simulation is widely used to complement ensemble-averaged
experiments of intrinsically disordered proteins (IDPs). However, MD often suffers from …
experiments of intrinsically disordered proteins (IDPs). However, MD often suffers from …
The influence of pH and monovalent/divalent cations on the structural and physicochemical properties of myofibrillar protein from silver carp
Y Wang, Y Zhuang, H Yan, Y Lu, X Deng, Y Hu… - Food Chemistry, 2023 - Elsevier
The present study aimed to investigate effects of pH and monovalent (Na+ and K+)/divalent
(Ca 2+ and Mg 2+) cations on the structural and physicochemical properties of myofibrillar …
(Ca 2+ and Mg 2+) cations on the structural and physicochemical properties of myofibrillar …
Universal and simple method for facile fabrication of sustainable high internal phase emulsions solely using meat protein particles with various pH values
R Li, Q He, M Guo, J Yuan, Y Wu, S Wang, L Rong… - Food …, 2020 - Elsevier
High internal phase emulsions (HIPEs) have recently been investigated for applications in
food areas: plant proteins, polysaccharides, and commercial surfactants have been used as …
food areas: plant proteins, polysaccharides, and commercial surfactants have been used as …
[HTML][HTML] Sequence charge decoration dictates coil-globule transition in intrinsically disordered proteins
We present an analytical theory to compute conformations of heteropolymers—applicable to
describe disordered proteins—as a function of temperature and charge sequence. The …
describe disordered proteins—as a function of temperature and charge sequence. The …
Structural preferences shape the entropic force of disordered protein ensembles
Intrinsically disordered protein regions (IDRs) make up over 30% of the human proteome
and exist in a dynamic conformational ensemble instead of a native, well-folded structure …
and exist in a dynamic conformational ensemble instead of a native, well-folded structure …
nP-Collabs: Investigating Counterion-Mediated Bridges in the Multiply Phosphorylated Tau-R2 Repeat
Tau is an intrinsically disordered (IDP) microtubule-associated protein (MAP) that plays a
key part in microtubule assembly and organization. The function of tau can be regulated by …
key part in microtubule assembly and organization. The function of tau can be regulated by …