Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome
The congenital short QT syndrome (SQTS) is a rare condition characterized by abbreviated
rate-corrected QT (QTc) intervals on the electrocardiogram and by increased susceptibility to …
rate-corrected QT (QTc) intervals on the electrocardiogram and by increased susceptibility to …
Emerging therapeutic targets in the short QT syndrome
ABSTRACT Introduction: Short QT Syndrome (SQTS) is a rare but dangerous condition
characterised by abbreviated repolarisation, atrial and ventricular arrhythmias and risk of …
characterised by abbreviated repolarisation, atrial and ventricular arrhythmias and risk of …
A new KCNQ1 mutation at the S5 segment that impairs its association with KCNE1 is responsible for short QT syndrome
C Moreno, A Oliveras, A De La Cruz… - Cardiovascular …, 2015 - academic.oup.com
Aims KCNQ1 and KCNE1 encode Kv7. 1 and KCNE1, respectively, the pore-forming and the
accessory subunits of the slow delayed rectifier potassium current, I Ks. KCNQ1 mutations …
accessory subunits of the slow delayed rectifier potassium current, I Ks. KCNQ1 mutations …
Preclinical short QT syndrome models: Studying the phenotype and drug-screening
X Fan, G Yang, J Kowitz, F Duru, AM Saguner… - EP …, 2022 - academic.oup.com
Cardiovascular diseases are the main cause of sudden cardiac death (SCD) in developed
and develo** countries. Inherited cardiac channelopathies are linked to 5–10% of SCDs …
and develo** countries. Inherited cardiac channelopathies are linked to 5–10% of SCDs …
Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling
Atrial fibrillation (AF) and sinus bradycardia have been reported in patients with short QT
syndrome variant 2 (SQT2), which is underlain by gain-of-function mutations in KCNQ1 …
syndrome variant 2 (SQT2), which is underlain by gain-of-function mutations in KCNQ1 …
Anti‐malarial drugs: Mechanisms underlying their proarrhythmic effects
Malaria remains the leading cause of parasitic death in the world. Artemisinin resistance is
an emerging threat indicating an imminent need for novel combination therapy. Given the …
an emerging threat indicating an imminent need for novel combination therapy. Given the …
Cellular targets of mefloquine
Mefloquine is a quinoline-based compound widely used as an antimalarial drug, particularly
in chemoprophylaxis. Although decades of research have identified various aspects of …
in chemoprophylaxis. Although decades of research have identified various aspects of …
In silico investigation of a KCNQ1 mutation associated with short QT syndrome
Short QT syndrome (SQTS) is a rare condition characterized by abnormally 'short'QT
intervals on the ECG and increased susceptibility to cardiac arrhythmias and sudden death …
intervals on the ECG and increased susceptibility to cardiac arrhythmias and sudden death …
Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome
The hERG potassium channel is critical to normal repolarization of cardiac action potentials
(AP s) and loss‐and gain‐of‐function hERG mutations are associated, respectively, with …
(AP s) and loss‐and gain‐of‐function hERG mutations are associated, respectively, with …
PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression
Y Ji, MG Veldhuis, J Zandvoort, FL Romunde… - Journal of Biomedical …, 2017 - Springer
Background The inward rectifier potassium current I K1 contributes to a stable resting
membrane potential and phase 3 repolarization of the cardiac action potential. KCNJ2 gain …
membrane potential and phase 3 repolarization of the cardiac action potential. KCNJ2 gain …