APP mouse models for Alzheimer's disease preclinical studies
H Sasaguri, P Nilsson, S Hashimoto, K Nagata… - The EMBO …, 2017 - embopress.org
Animal models of human diseases that accurately recapitulate clinical pathology are
indispensable for understanding molecular mechanisms and advancing preclinical studies …
indispensable for understanding molecular mechanisms and advancing preclinical studies …
Molecular dynamics simulations and novel drug discovery
X Liu, D Shi, S Zhou, H Liu, H Liu… - Expert opinion on drug …, 2018 - Taylor & Francis
Introduction: Molecular dynamics (MD) simulations can provide not only plentiful dynamical
structural information on biomacromolecules but also a wealth of energetic information …
structural information on biomacromolecules but also a wealth of energetic information …
Amyloid β protein and Alzheimer's disease: When computer simulations complement experimental studies
Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …
[HTML][HTML] Visualizing and trap** transient oligomers in amyloid assembly pathways
Oligomers which form during amyloid fibril assembly are considered to be key contributors
towards amyloid disease. However, understanding how such intermediates form, their …
towards amyloid disease. However, understanding how such intermediates form, their …
Risk factors for Alzheimer's disease
RA Armstrong - Folia neuropathologica, 2019 - termedia.pl
Early reviews identified over 20 risk factors associated with Alzheimer's disease (AD)
including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and …
including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and …
What causes Alzheimer's disease?
RA Armstrong - Folia neuropathologica, 2013 - termedia.pl
Since the earliest descriptions of Alzheimer's disease (AD), many theories have been
advanced as to its cause. These include:(1) exacerbation of aging,(2) degeneration of …
advanced as to its cause. These include:(1) exacerbation of aging,(2) degeneration of …
Amyloid β-protein oligomers and Alzheimer's disease
EY Hayden, DB Teplow - Alzheimer's research & therapy, 2013 - Springer
The oligomer cascade hypothesis, which states that oligomers are the initiating pathologic
agents in Alzheimer's disease, has all but supplanted the amyloid cascade hypothesis …
agents in Alzheimer's disease, has all but supplanted the amyloid cascade hypothesis …
Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance
E Atrián-Blasco, P Gonzalez, A Santoro, B Alies… - Coordination chemistry …, 2018 - Elsevier
Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …
their development. This is the case of important neurodegenerative diseases such as …
Familial Alzheimer's disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid-β peptide
Most cases of Alzheimer's disease (AD) are sporadic, but a small percentage of AD cases,
called familial AD (FAD), are associated with mutations in presenilin 1, presenilin 2, or the …
called familial AD (FAD), are associated with mutations in presenilin 1, presenilin 2, or the …
Alzheimer's disease: How metal ions define β-amyloid function
KP Kepp - Coordination Chemistry Reviews, 2017 - Elsevier
Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …